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Clinical Trials in Egypt / NCT05896189
Active, not recruiting Not applicable

Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors

NCT05896189 · tracked via the Priya Life Science Egypt tracker
Phase
Not applicable
Started
2024-02-29
Last updated
2026-07-30

Condition(s) studied

Breast CancerCognitive Impairments

Investigational drug(s) / intervention(s)

Arm 1: Computerized Cognitive Training-Global Stimulation GamesArm 2: Computerized Cognitive Training-Neuroplasticity Games

Arm 1: Computerized Cognitive Training-Global Stimulation Games: The program will includes 8 non-speeded exercises that include spin-offs of such games as breaking hex, lineup four, battleship, gems swap, double klondike, solitaire, reversi, word search, and sudoku. These games are well matched for time on task, novelty, and progression across levels. These are strategy-based games without adaptive, speeded, or accuracy-based algorithms underlying their personalization.

Arm 2: Computerized Cognitive Training-Neuroplasticity Games: Cognitive training exercises include Double Decision (targets visual speed of processing and useful field of view), Target Tracker (targets visuospatial working memory capacity), Visual Sweeps (targets speed of processing), Syllable Stacks (targets auditory memory), Eye for Detail (targets eye movement speed and visuo-spatial working memory), Mind Bender (targets mental flexibility), Divided Attention (a shape-color-pattern inhibitory control exercise that focuses on rapidly determining whether flashing colors, shapes, or patterns meet a pre-specified rule), Right Turn (targets spatial reasoning).

Study summary

This Phase III trial will examine the efficacy of computerized cognitive training methods on perceived cognitive impairment in breast cancer survivors.

Eligibility

Sex
ALL
Min age
18 Years
Max age
100 Years
Healthy volunteers
No
Inclusion Criteria: * The participant must provide study-specific informed consent prior to any study specific procedures and authorization permitting release of personal health information. * The participant must have a first time diagnosis of non-metastatic breast cancer which is Stage I-III. * The participant must have a score of less than 12 on the PROMIS Adult v2.0 - Cognitive Function 4a. * Participants must be at least 6 months and no more than 5 years (after completion of initial surgery +/- adjuvant chemotherapy/radiation therapy) and targeted therapies (e.g., PARP inhibitors, CDK4/6, or immunotherapy). Participants may still be taking endocrine therapy and/or trastuzumab. * The participant must be able to understand, speak, read, and write in English or Spanish. Exclusion Criteria: * Scoring less than or equal to 3 on the 6-item cognitive screen. * Patient Health Questionnaire-2 item (PHQ-2) score of greater than or equal to 3. * Definitive clinical or radiologic evidence of metastatic disease. * Current or past history of another cancer. Patients with history of only non-melanoma skin cancer or in situ cervical cancer without chemotherapy treatment would be eligible. * Previous exposure to chemotherapy treatment for another cancer or due to other medical condition (e.g. methotrexate exposure for treatment of rheumatoid arthritis). * Previous central nervous system (CNS) radiation, intrathecal therapy or CNS-involved surgery. * Participants with history of stroke, traumatic brain injury, brain surgery, Alzheimer's disease or other dementia. * Participants with active substance abuse and/or in treatment for substance abuse, or history of bipolar disorder, psychosis, schizophrenia, ADHD, or learning disability. * Participants who are enrolled in an active behavioral intervention (e.g., occupational therapy, physical therapy, etc.) or pharmaceutical intervention or who are in the follow-up phase of a cancer control trial or therapeutic trial that has extensive PRO follow-up after treatment ends. Participants who are enrolled in a therapeutic trial in which they have completed active treatment and require only minimal follow-up monitoring of toxicity and/or survival analysis (cancer-related mortality or all-cause mortality) would be eligible. * Hearing impairment unless adequately corrected with hearing aids to be able to hear over the phone for the neuropsychological testing.

Primary outcome measure(s)

Trial sites (680)

FacilityCityRegionStatus
Anchorage Associates in Radiation Medicine Anchorage Alaska
Anchorage Radiation Therapy Center Anchorage Alaska
Alaska Breast Care and Surgery LLC Anchorage Alaska
Alaska Oncology and Hematology LLC Anchorage Alaska
Alaska Women's Cancer Care Anchorage Alaska
Katmai Oncology Group Anchorage Alaska
Providence Alaska Medical Center Anchorage Alaska
Fairbanks Memorial Hospital Fairbanks Alaska
Arizona Center for Cancer Care - Gilbert Gilbert Arizona
CTCA at Western Regional Medical Center Goodyear Arizona
Arizona Center for Cancer Care-Peoria Peoria Arizona
Cancer Center at Saint Joseph's Phoenix Arizona
Arizona Center for Cancer Care - Biltmore Phoenix Arizona
Arizona Center for Cancer Care - Phoenix Phoenix Arizona
Mayo Clinic Hospital in Arizona Phoenix Arizona
Arizona Center for Cancer Care - Osborn Scottsdale Arizona
Arizona Center for Cancer Care - Scottsdale Scottsdale Arizona
Arizona Center for Cancer Care-Surprise Surprise Arizona
Arizona Center for Cancer Care Tempe Arizona
Mercy Hospital Fort Smith Fort Smith Arkansas
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro Arkansas
CARTI Cancer Center Little Rock Arkansas
Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande California
AIS Cancer Center at San Joaquin Community Hospital Bakersfield California
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California
Marshall Cancer Center Cameron Park California
Mercy Cancer Center - Carmichael Carmichael California
Mercy San Juan Medical Center Carmichael California
Enloe Medical Center Chico California
Kaiser Permanente Dublin Dublin California
Mercy Cancer Center - Elk Grove Elk Grove California
Kaiser Permanente-Fremont Fremont California
Washington Hospital Fremont California
Fresno Cancer Center Fresno California
Kaiser Permanente Fresno Orchard Plaza Fresno California
Kaiser Permanente-Fresno Fresno California
Cedars Sinai Medical Center Los Angeles California
UCLA / Jonsson Comprehensive Cancer Center Los Angeles California
Contra Costa Regional Medical Center Martinez California
Fremont - Rideout Cancer Center Marysville California

+ 640 more sites — see the full list on the official registry below.

More NRG Oncology trials in Egypt

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05896189 on ClinicalTrials.gov ↗ ← All trials in Egypt