Non-Invasive Malignancy Classifiers Using Blood-Biomarkers for Lung Nodule Evaluation

NCT07623473 · tracked via the Priya Life Science Denmark tracker

Sponsor

Herlev and Gentofte Hospital

Phase

Observational

Started

2024-05-22

Last updated

2026-06-03

Condition(s) studied

Lung Cancer (Diagnosis)Nodule, Solitary Pulmonary

Investigational drug(s) / intervention(s)

Blood tests

Blood tests: Standard blood tests, Novel protein tumor markers specifically targeting lung cancer, Epigenetic smoking marker (AHRR methylation), Combined fragmentome, mutational and methylome analysis of cell-free tumor DNA

Study summary

The goal of the NIMBLE study is to evaluate blood-based biomarkers for lung cancer risk prediction in patients referred with a lung nodule.

Each blood biomarker will be evaluated for descriminating malignant from benign lung nodules alone and in combination with other blood biomarkers, patient characteristics and radiological features.

Eligibility

Sex

ALL

Min age

—

Max age

—

Healthy volunteers

Accepted

Inclusion Criteria: * Patients with a newly detected IPN suspected of lung cancer referred to the infiltrate unit * Having signed informed consent Exclusion Criteria: * Active cancer, excluding non-melanoma skin cancer * Comorbidities that exclude the patient from clinical follow-up and final diagnosis

Primary outcome measure(s)

Lung cancer diagnosis during work-up — At least two years of followup

Trial sites (1)

Facility	City	Region	Status
Gentofte Hospital	Gentofte Municipality	Denmark	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07623473 on ClinicalTrials.gov ↗ ← All trials in Denmark