Dexamethasone: Patients will receive either low dose (8mg) or high dose (1mg/kg)
Study summary
The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in patients undergoing VATS lobectomy/segmentectomy.
The hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy/segmentectomy, in patients scoring as "High-pain-responders" on the Pain-Catastrophizing-Scale
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Age ≥ 18 year
* Able to understand written and spoken Danish language
* PCS ≥20
* Signed written informed consent form.
* Patient planned to elective VATS lobectomy/segmentectomy
Exclusion Criteria:
* Patients undergoing systemic glucocorticoid or other immunosuppressive therapies, ex-cluding inhaled steroids.
* Individuals with diabetes requiring insulin treatment.
* Pregnant or breastfeeding patients.
* Patients with known allergies to the study drug.
* Individuals with mental disabilities that may impair their capacity to provide informed consent or compromise the validity of data collection.
* Patients with diagnosed schizophrenia, active psychosis, bipolar disorder, or a history of ongoing treatment with antipsychotic and/or antidepressant medications.
* Individuals with altered pain perception due to other conditions or injuries, such as spi-nal cord or brain injuries, severe polyneuropathies, or neurological disorders.
* Regular users of opioid medications.
* Patients requiring reoperation within the first two postoperative days.
* Individuals undergoing conversion to a surgical procedure other than VATS lobecto-my/segmentectomy.
Primary outcome measure(s)
Pain when coughing on the morning of first postoperative day. — Morning of first postoperative day The primary endpoint is pain when coughing on the first morning after surgery, measured on the NRS-scale (0-10; where 0 is no pain, and 10 is the worst possible pain).
Trial sites (1)
Facility
City
Region
Status
Department for Cardiothoracic Surgery, Rigshospitalet
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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