In this study the investigators will, with an Magnetic Resonance Imaging (MRI) method, measure the oxygen content in the portal vein, which conduct the blood from the guts to the liver. Examinations will be performed on 20 subjects with meal related abdominal pain due to severe narrowing of the vessels conduction blood to the guts,compared to 20 subjects with similar narrowing of the abdominal vessels, but without meal related pain. The goal of the study is to test a non-invasive, radiation free method to diagnose patients with abdominal pain due to compromized blood supply (chronic mesenteric ischemia).
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* \- Written informed consent
* Male or female persons \> 18 years
* Subjects with postprandial abdominal pain considered compatible with mesenteric ischemia, and severe stenosis of the SMA and eventually other mesenteric arteries, diagnosed with CT-angiography or Doppler ultrasound
* OR subjects with severe stenosis of the SMA and eventually other mesenteric arteries, diagnosed with CT-angiography or Doppler ultrasound, but not postprandial pain
Exclusion Criteria:
* \- Serious concurrent illness
* BMI \> 30
* Cardiac arrhythmia
* Anemia with Hgb \< 7,0 mmol/l
* Pregnancy or breastfeeding (urine HCG is performed on all fertile women)
* Systolic blood pressure \< 90 or \> 200 mmHg
* Claustrophobia
* Patients who, in the judgement of the investigator, is incapable of participating
* Metallic foreign objects in the body, or pacemakers
Primary outcome measure(s)
flow and oxygen concentration in the portal vein — From enrollment Through study completion, an average of 2 years Fasting and postprandial flow and oxygen concentration in the portal vein, measured by MRI
Trial sites (1)
Facility
City
Region
Status
Dept. of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.