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Clinical Trials in Denmark / NCT07182669
Starting soon Observational

Blood Flow and Oxygenation in the Portal Vein in Subjects With Chronic Narrowing of the Blood Vessels to the Gut

NCT07182669 · tracked via the Priya Life Science Denmark tracker
Sponsor
Copenhagen University Hospital, Rigshospitalet
Phase
Observational
Started
2025-10-01
Last updated
2025-09-19

Condition(s) studied

Chronic Mesenteric Ischemia

Study summary

In this study the investigators will, with an Magnetic Resonance Imaging (MRI) method, measure the oxygen content in the portal vein, which conduct the blood from the guts to the liver. Examinations will be performed on 20 subjects with meal related abdominal pain due to severe narrowing of the vessels conduction blood to the guts,compared to 20 subjects with similar narrowing of the abdominal vessels, but without meal related pain. The goal of the study is to test a non-invasive, radiation free method to diagnose patients with abdominal pain due to compromized blood supply (chronic mesenteric ischemia).

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * \- Written informed consent * Male or female persons \> 18 years * Subjects with postprandial abdominal pain considered compatible with mesenteric ischemia, and severe stenosis of the SMA and eventually other mesenteric arteries, diagnosed with CT-angiography or Doppler ultrasound * OR subjects with severe stenosis of the SMA and eventually other mesenteric arteries, diagnosed with CT-angiography or Doppler ultrasound, but not postprandial pain Exclusion Criteria: * \- Serious concurrent illness * BMI \> 30 * Cardiac arrhythmia * Anemia with Hgb \< 7,0 mmol/l * Pregnancy or breastfeeding (urine HCG is performed on all fertile women) * Systolic blood pressure \< 90 or \> 200 mmHg * Claustrophobia * Patients who, in the judgement of the investigator, is incapable of participating * Metallic foreign objects in the body, or pacemakers

Primary outcome measure(s)

  • flow and oxygen concentration in the portal vein — From enrollment Through study completion, an average of 2 years
    Fasting and postprandial flow and oxygen concentration in the portal vein, measured by MRI

Trial sites (1)

FacilityCityRegionStatus
Dept. of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet Copenhagen State

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07182669 on ClinicalTrials.gov ↗ ← All trials in Denmark