Immediate FET in a stimulated or programmed cycle: Patients will undergo FET in the cycle immediately following oocyte retrieval and a failed fresh embryo transfer or freeze all.
Study summary
The aim of this randomized controlled trial is to examine whether single blastocyst transfer in the first cycle after oocyte retrieval (immediate) is non-inferior to single blastocyst transfer in a subsequent cycle (postponed) in stimulated or programmed cycle frozen embryo transfer (FET). The primary outcome is live birth rate.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
40 Years
Healthy volunteers
No
Inclusion Criteria:
* Eligible for FET in a programmed- or stimulated cycle immediately following a fresh embryo transfer or freeze all cycle
* Oligo-anovulatory women (cycle length \> 35 days)
* Ovulatory women (cycle length 21-35 days)
* At least one vitrified day 5 or 6 blastocyst with Gardner score of ≥ 3BB at the day of vitrification
Exclusion Criteria:
* Uterine malformation
* Presence of hydrosalpinx, submucosal uterine myomas or uterine polyps
* Allergies or contraindication to standard fertility medication
* Male or female HIV or Hepatitis B or C
* Preimplantation genetic testing (PGT) in the fresh cycle
* Testicular sperm aspiration (TESA)
* Severe OHSS with hospital admission and ascites drainage during the fresh cycle
* Oocyte donation
Primary outcome measure(s)
Live birth rate — One year follow up from positive pregnancy test. Live birth rate in immediate FET compared to postponed FET in women undergoing FET in a stimulated or programmed cycle.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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