Bicarbonate for In-Hospital Cardiac Arrest

NCT05564130 · tracked via the Priya Life Science Denmark tracker

Sponsor

Lars Wiuff Andersen

Phase

Phase 4

Started

2023-02-06

Last updated

2026-02-17

Condition(s) studied

Cardiac Arrest

Investigational drug(s) / intervention(s)

Sodium bicarbonate →Sodium chloride

Sodium bicarbonate: Sodium bicarbonate 1 mmol/ml

Sodium chloride: Sodium chloride 9 mg/mL

Study summary

This is an investigator-initiated, multicenter, randomized, placebo-controlled, parallel group, double-blind, superiority trial of sodium bicarbonate during adult in-hospital cardiac arrest. There will be 22 enrolling sites in Denmark. 778 adult patients with in-hospital cardiac arrest receiving at least one dose of adrenaline will be enrolled. The primary outcome is return of spontaneous circulation and key secondary outcomes include survival at 30 days and survival at 30 days with a favorable neurological outcome.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: 1. In-hospital cardiac arrest 2. Age ≥ 18 years 3. Received at least one dose of adrenaline during cardiopulmonary resuscitation (CPR) Exclusion Criteria: 1. Clearly documented "do-not-resuscitate" order prior to the cardiac arrest 2. Prior enrollment in the trial 3. Invasive mechanical circulatory support at the time of the cardiac arrest 4. Known or suspected pregnancy at the time of the cardiac arrest 5. Known objection by the patient to participate in the trial 6. Clinical indication for bicarbonate administration

Primary outcome measure(s)

Number of Participants With Return of Spontaneous Circulation — During the cardiac arrest, an average of 20 minutes
Return of spontaneous circulation is defined as spontaneous circulation with no further need for chest compressions sustained for at least 20 minutes

Trial sites (22)

Facility	City	Region
Hospital of Southern Jutland - Aabenraa	Aabenraa	Denmark
Aalborg University Hospital	Aalborg	Denmark
Aarhus University Hospital	Aarhus	Denmark
Copenhagen University Hospital - Bispebjerg	Bispebjerg	Denmark
Copenhagen University Hospital - Rigshospitalet	Copenhagen	Denmark
Hospital of Southwest Jutland - Esbjerg	Esbjerg	Denmark
Copenhagen University Hospital - Gentofte	Gentofte Municipality	Denmark
Gødstrup Hospital	Gødstrup	Denmark
Copenhagen University Hospital - Herlev	Herlev	Denmark
North Denmark Region Hospital - Hjørring	Hjørring	Denmark
Holbæk Hospital	Holbæk	Denmark
Horsens Regional Hospital	Horsens	Denmark
Hvidovre Hospital	Hvidovre	Denmark
Kolding Hospital	Kolding	Denmark
Zealand University Hospital - Køge	Køge	Denmark
Nykøbing Falster Hospital	Nykøbing Falster	Denmark
Odense University Hospital	Odense	Denmark
Randers Regional Hospital	Randers	Denmark
Zealand University Hospital - Roskilde	Roskilde	Denmark
Slagelse Hospital	Slagelse	Denmark
Odense University Hospital - Svendborg	Svendborg	Denmark
Viborg Regional Hospital	Viborg	Denmark

More Lars Wiuff Andersen trials in Denmark

Intravenous Vs. Intraosseous Vascular Access During Out-of-Hospital Active, not recruiting

Strategies for Defibrillation During Out-of-Hospital Cardiac Arrest Recruiting

Other trials for the same condition

COMPuter-assisted Self-training to Improve EXecutive Function Recruiting

Resuscitative Endovascular Balloon Occlusion of the Aorta in Non-traumatic Out of Hospital Cardiac Arrest Active, not recruiting

Intravenous Vs. Intraosseous Vascular Access During Out-of-Hospital Active, not recruiting

Rehabilitation for Survivors of Out-of-hospital Cardiac Arrest Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05564130 on ClinicalTrials.gov ↗ ← All trials in Denmark