Electrical Impedance Tomography-Guided Identification of the Optimal Lateral Position in Postoperative ARDS

NCT07669558 · tracked via the Priya Life Science China tracker

Sponsor

Ruijin Hospital

Phase

Not applicable

Started

2026-06-28

Last updated

2026-08-03

Condition(s) studied

Acute Respiratory Distress Syndrome (ARDS)Postoperative

Investigational drug(s) / intervention(s)

Positioning Intervention

Positioning Intervention: Using a randomized crossover design, all subjects undergo three body position stages in random order. Each position (supine, left lateral, right lateral) is maintained for 60 minutes. Vital signs are stabilized per protocol, followed by EIT assessment of ventilation-perfusion matching. 1. Position stage duration: 60 minutes. 2. Stabilization period before measurement: 45 minutes after position change. 3. Washout: 45-minute supine washout period between position stages. 4. EIT ventilation measurement: after stabilization in each position. 5. EIT perfusion measurement: during breath-hold ≥8 seconds (actual breath-hold time recorded. 6. Tracer bolus: 10 mL of 10% sodium chloride solution OR 10 mL of 5% sodium bicarbonate solution, injected over 2-3 seconds via central or peripheral venous line.

Study summary

This prospective, randomized crossover physiological study evaluates the effects of lateral positioning (left lateral position and right lateral position) versus the supine position on ventilation-perfusion (V/Q) matching in adult postoperative abdominal surgery participants with acute respiratory distress syndrome (ARDS). Bedside electrical impedance tomography (EIT) will be used to quantify regional ventilation and perfusion (perfusion derived from an intravenous tracer bolus administered during a brief breath-hold) and to calculate global "normal V/Q" (normal V/Q, %). Oxygenation, respiratory mechanics (when applicable), and hemodynamics will be recorded concurrently. Feasibility and safety of the positioning protocol will also be assessed.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age ≥18 years * Postoperative abdominal surgery patients admitted to the ICU with ARDS (Berlin definition) * Considered able to tolerate protocolized position changes by the treating team * EIT belt placement and protocol procedures feasible * Informed consent obtained from the patient or legally authorized representative Exclusion Criteria: * Contraindication to lateral positioning (e.g., unstable spine, uncontrolled bleeding, open abdomen, high-risk surgical wound condition) * Severe hemodynamic instability or other conditions making participation unsafe * High risk of airway/vascular line/drain dislodgement not manageable * Pregnancy * Refusal of informed consent * Any other condition deemed inappropriate by investigators

Primary outcome measure(s)

Global normal V/Q (%) derived from electrical impedance tomography (EIT) — Post-stabilization in each body position (supine, left lateral, right lateral); assessments performed once per 60-minute positional stage, with comparative data reported for each position time point.
The percentage of lung pixels categorized as "normal ventilation-perfusion (V/Q)" according to pre-defined ventilation and perfusion signals acquired via EIT.

Trial sites (1)

Facility	City	Region	Status
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Department of Critical Care Medicine	Shanghai	China	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07669558 on ClinicalTrials.gov ↗ ← All trials in China