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Clinical Trials in China / NCT07553845
Recruiting Observational

A Multimodal Prospective Cohort Study of Parkinsonism

NCT07553845 · tracked via the Priya Life Science China tracker
Sponsor
Ruijin Hospital
Phase
Observational
Started
2024-05-01
Last updated
2026-04-28

Condition(s) studied

ParkinsonismREM Sleep Behavior Disorder

Study summary

This is a single-center, prospective, observational cohort study designed to investigate the progression and differential diagnosis of Parkinsonism using a multimodal approach. The study plans to enroll 400 patients with Parkinsonism, 120 patients with rapid eye movement sleep behavior disorder, and 120 healthy controls, with follow-up for 5 years.

Assessments will include neuroimaging, clinical rating scales, biological samples, blood flow evaluation, neurophysiological testing, tremor analysis, and voice and video assessments. The study aims to characterize disease progression, explore factors associated with progression from rapid eye movement sleep behavior disorder to Parkinsonism, and improve the ability to distinguish among different Parkinsonian disorders.

Eligibility

Sex
ALL
Min age
31 Years
Max age
79 Years
Healthy volunteers
Accepted
Inclusion Criteria: For participants with rapid eye movement sleep behavior disorder: * Meets the diagnostic criteria for rapid eye movement sleep behavior disorder established by the American Academy of Sleep Medicine * Chinese citizen * Age \>30 years and \<80 years * Able to understand the study, show good compliance, and provide written informed consent personally or through a legal representative For participants with Parkinsonism: * Meets the diagnostic criteria for Parkinsonism established by the International Parkinson and Movement Disorder Society * Chinese citizen * Age \>30 years and \<80 years * Able to understand the study, show good compliance, and provide written informed consent personally or through a legal representative For healthy controls: * No neurodegenerative disease, no history of head trauma or head surgery, no history of stroke, epilepsy, tumor, or psychiatric disease * No metal implants or cardiac pacemaker * No severe chronic disease or severe hepatic or renal insufficiency * Chinese citizen * Age \>30 years and \<80 years * Education level of primary school or above * Able to understand the study, show good compliance, and provide written informed consent personally or through a legal representative Exclusion Criteria: * Significant cognitive impairment (MMSE ≤23) * Unable to sign the informed consent form or unable to complete study procedures for other reasons * Any other condition that, in the opinion of the investigator, makes the participant unsuitable for this study

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Department of neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07553845 on ClinicalTrials.gov ↗ ← All trials in China