3-Dimensional Simulation Guided Transcatheter Aortic Valve Replacement in Aortic Regurgitation(DIGITAL)

Inclusion Criteria: * All of the following conditions must be met for inclusion: 1. Age ≥ 65 years; 2. Symptomatic severe native aortic regurgitation; 3. Aortic valve anatomy assessed by investigator as suitable for transcatheter aortic valve replacement ; 4. Subjects signed a written informed consent and agreed to cooperate with all follow-up examinations. Exclusion Criteria: * Patients meeting any of the following exclusion criteria were not included: 1. Active endocarditis; 2. Acute myocardial infarction or unstable angina pectoris, or severe coronary stenosis requiring coronary revascularization within 3 months; 3. Stroke or TIA (transient ischemic attack) within the past 3 months; 4. Any intracardiac mass, left ventricular or atrial thrombus, vegetation detected by echocardiography; 5. Severe obstructive hypertrophic cardiomyopathy (LVOTG peak ≥ 30 mmHg at rest); Note: Literature Basis: Chinese Guidelines for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy 2023 6. History of bleeding tendency or coagulopathy or refusal of blood transfusion; 7. Active gastric ulcer or active gastrointestinal (GI) bleeding within 3 months; 8. Presence of contraindication to anticoagulation or antiplatelet; 9. Complicated with severe other valve diseases requiring concurrent surgical intervention; 10. Prior aortic valve graft (mechanical or bioprosthetic); 11. Severe left ventricular dysfunction, left ventricular ejection fraction \< 30%; 12. Hepatic encephalopathy or acute active hepatitis; 13. Renal dysfunction (eGFR \< 30ml/min calculated according to Cockcroft-Gault formula) and/or ongoing renal replacement therapy; 14. Patients with severe dementia and other poor compliance, unable to ensure the completion of the investigator; 15. Emergency surgery required for any reason; 16. Known hypersensitivity to contrast agents or nitinol memory alloys or porcine products; 17. Patients who are pregnant or plan to become pregnant, or are taking estrogen or estrogen-like drugs (women suspected of becoming pregnant must have a negative serum or urine test for human chorionic gonadotropin before being included in the study); 18. Other patients considered unsuitable for this clinical study by the investigator;