University of Electronic Science and Technology of China
Phase
Not applicable
Started
2025-10-09
Last updated
2026-01-27
Condition(s) studied
Healthy Male and Female Volunteers
Investigational drug(s) / intervention(s)
taVNS on tragus of subjects with high trait anxietytaVNS on earlobe of subjects with high trait anxietytaVNS on tragus of subjects with no high trait anxietytaVNS on earlobe of subjects with no high trait anxiety
taVNS on tragus of subjects with high trait anxiety: 15 minutes taVNS on tragus
taVNS on earlobe of subjects with high trait anxiety: 15 minutes taVNS on earlobe
taVNS on tragus of subjects with no high trait anxiety: 15 minutes taVNS on tragus
taVNS on earlobe of subjects with no high trait anxiety: 15 minutes taVNS on earlobe
Study summary
The main aim of this study is to investigate whether transcutaneous auricular vagus nerve stimulation (taVNS) can reduce anxiety and have an effect on emotional regulations
Eligibility
Sex
ALL
Min age
18 Years
Max age
30 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Healthy subjects without past or current psychiatric or neurological disorders.
Exclusion Criteria:
* History of head injury.
* Medical or psychiatric illness.
* Subjects take a certain drug for a long period of time.
* Subjects have metal implants in their bodies.
Primary outcome measure(s)
Brain activity patterns in response to negative pictures during emotional regulation — 60 minutes Subjects will receive task-based fMRI scanning (i.e., the modified emotional regulation task) after taVNS and two resting-state fMRI scanning sessions. We will examine these brain response patterns in the modified emotional regulation task via both the conventional univariate analysis and the machine learning-based multivariate pattern analysis.
Resting-state functional conetivity changes — 15 minutes Subjects will receive resting-state fMRI scanning twice before and after taVNS. We will examine resting-state functional conetivity changes induced by taVNS via examining functional conetivity differences between pre- and post-taVNS sessions.
Behavioral indices in the task — 60 minutes Anxiety and success ratings after each regulation trial are recorded in the task. Subjects are instructed to rate their anxiety and success levels using a 9-point Likert scale within 4 seconds (1 = not at all, 9 = very anxious or successful)
Trial sites (1)
Facility
City
Region
Status
University of Electronic Science and Technology of China (UESTC)
Chengdu
Sichuan
Recruiting
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