Laparoscopic Partial Splenectomy for Hypersplenism in Liver Cirrhosis Patients

Condition(s) studied

Investigational drug(s) / intervention(s)

Laparoscopic Partial Splenectomy: The laparoscopic partial splenectomy technique involved preserving the short gastric vessels and the splenic suspensory ligament, with resection conducted along the demarcation line.

Study summary

In this study,the researchers compared the changes in immune function-related indicators in patients with liver cirrhosis following laparoscopic partial splenectomy,to determine whether this surgical intervention can enhance postoperative immune function and thereby improve patient outcomes.

Eligibility

Primary outcome measure(s)

• Change in Humoral Immune Markers from Baseline to 6 Months Postoperation — Baseline (preoperative) and 6 months postoperation
  Serum levels of immunoglobulins (IgG, IgA, IgM), complement proteins (C3, C4), and B-cell markers (CD19, CD20) will be measured. The primary outcome is the change in these markers from preoperative baseline to 6 months after surgery.
• Platelet Count at 6 Months Postoperation — 6 months postoperation
  Platelet count (×10⁹/L) will be measured and compared between the two surgical groups.
• White Blood Cell Count at 6 Months Postoperation — 6 months postoperation
  White blood cell count (×10⁹/L) will be compared between groups.
• Hemoglobin Level at 6 Months Postoperation — 6 months postoperation
  Hemoglobin concentration (g/L) will be compared between groups.
• Blood Flow Velocity of the Portal Vein at 6 Months Postoperation — 6 months postoperation
  Blood flow velocity (cm/s) in the portal vein, measured by Doppler ultrasound, will be compared between groups.
• Vascular Diameter of the Portal Vein at 6 Months Postoperation — 6 months postoperation
  Vascular diameter (mm) of the portal vein, measured by Doppler ultrasound, will be compared between groups.
• Blood Flow Velocity of the Splenic Vein at 6 Months Postoperation — 6 months postoperation
  Blood flow velocity (cm/s) in the splenic vein, measured by Doppler ultrasound, will be compared between groups.
• Vascular Diameter of the Splenic Vein at 6 Months Postoperation — 6 months postoperation
  Vascular diameter (mm) of the splenic vein, measured by Doppler ultrasound, will be compared between groups.
• Indocyanine Green Retention Rate at 15 Minutes (ICG R15) at 6 Months Postoperation — 6 months postoperation
  Indocyanine green retention rate at 15 minutes (%), a measure of liver function, will be compared between groups.
• Incidence of Portal Venous System Thrombosis within 6 Months Postoperation — 6 months postoperation
  The number of participants with newly developed thrombosis in the portal venous system, confirmed by imaging, will be recorded and compared.

Trial sites (1)

More Northern Jiangsu People's Hospital trials in China

Other trials for the same condition