The Effect of Laparoscopic Splenectomy on Liver Reserve Function for Cirrhosis Patients

NCT05325424 · tracked via the Priya Life Science China tracker

Sponsor

Northern Jiangsu People's Hospital

Phase

Not applicable

Started

2022-03-01

Last updated

2025-05-30

Condition(s) studied

Cirrhosis, LiverSplenectomy; Status

Investigational drug(s) / intervention(s)

Laparoscopic splenectomy

Laparoscopic splenectomy: The laparoscopic splenectomy was performed by the same surgical team.

Study summary

In this study, the investigators compared the improvement of liver reserve function related indicators in patients with liver cirrhosis after laparoscopic splenectomy. To determine whether surgical treatment can help enhance postoperative liver reserve function and improve patient prognosis.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * A clinical, radiological or histologic diagnosis of cirrhosis of any etiology * Splenomegaly with secondary hypersplenism, Platelet count \< 50\*10\^9/L * Informed consent to participate in the study Exclusion Criteria: * Hepatocellular carcinoma or any other malignancy, * Child-Pugh grade C * Recent peptic ulcer disease * History of Hemorrhagic stroke * Pregnancy. * Uncontrolled Hypertension * Bleeding portal hypertension * Human immunodeficiency virus (HIV) infection

Primary outcome measure(s)

Liver reserve function ICG-K level at 3 months after surgery — 3 months
The level of liver reserve function ICG-K level at 3 months after surgery.
Liver reserve function ICG-K level at 6 months after surgery. — 6 months
The level of liver reserve function ICG-K level at 6 months after surgery.
Liver reserve function ICG-K level at 12 months after surgery — 12 months
The level of liver reserve function ICG-K level at 12 months after surgery.
Liver reserve function ICG-K level at 24 months after surgery. — 24 months
The level of liver reserve function ICG-K level at 24 months after surgery.
Liver reserve function ICG-R15 level at 3 months after surgery. — 3 months
The level of liver reserve function ICG-R15 level at 3 months after surgery.
Liver reserve function ICG-R15 level at 6 months after surgery. — 6 months
The level of liver reserve function ICG-R15 level at 6 months after surgery.
Liver reserve function ICG-R15 level at 12 months after surgery. — 12 months
The level of liver reserve function ICG-R15 level at 12 months after surgery.
Liver reserve function ICG-R15 level at 24 months after surgery. — 24 months
The level of liver reserve function ICG-R15 level at 24 months after surgery.
Liver reserve function ICG-T/2 level at 3 months after surgery. — 3 months
The level of liver reserve function ICG-T/2 level at 3 months after surgery.
Liver reserve function ICG-T/2 level at 6 months after surgery. — 6 months
The level of liver reserve function ICG-T/2 level at 6 months after surgery.
Liver reserve function ICG-T/2 level at 12 months after surgery. — 12 months
The level of liver reserve function ICG-T/2 level at 12 months after surgery.
Liver reserve function ICG-T/2 level at 24 months after surgery. — 24 months
The level of liver reserve function ICG-T/2 level at 24 months after surgery.

Trial sites (1)

Facility	City	Region	Status
Clinical Medical College of Yangzhou University	Yangzhou	Jiangsu	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05325424 on ClinicalTrials.gov ↗ ← All trials in China