Chronic Airway Disease and Multimorbidity Cohort

NCT06798077 · tracked via the Priya Life Science China tracker

Sponsor

China-Japan Friendship Hospital

Phase

Observational

Started

2025-02-01

Last updated

2025-02-17

Condition(s) studied

Chronic Obstructive Pulmonary Disease (COPD)AsthmaBronchiectasis

Study summary

Background: Chronic airway diseases (CAD), including chronic obstructive pulmonary disease (COPD), asthma and bronchiectasis, are highly prevalent and cause serious disease burden. Multimorbidity is recognized to influence treatment decision and prognosis of patients with stable CAD. The impact of multimorbidity on exacerbation CAD is under investigated.

Methods: The Chronic Airway Disease and Multimorbidity (CAM) cohort study is a prospective, multicenter, observational study aiming to recruit a minimum of 2000 patients hospitalized for exacerbation of COPD, asthma or bronchiectasis. Comprehensive data, including demographics, medical history, comorbidities, lung function, echocardiography, microbiological profiles, radiology, quality of life and treatment will be collected at baseline during the hospitalization. Follow-up data indicating the impact of both CAD and multimorbidity will be collected at 1-, 3-, 6-, 9- and 12-months after hospital discharge. Biospecimens, including blood and bronchoalveolar lavage fluid, will be collected and analyzed for biomarker detecting. Primary outcome are length of hospital stay and re-exacerbation during fellow-up. Secondary outcomes include comorbidity pattern and its impact on respiratory symptoms burden, quality of life, pulmonary function and chest imaging as well as cost and healthcare utilization.

Conclusions: The knowledge generated from CAM cohort study will fill crucial gaps in understanding how multimorbidity affects CAD and facilitate evidence-based clinical practice in the future.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Patients with chronic obstructive pulmonary disease ≥40 years of age; patients with asthma and bronchiectasis ≥18 years of age; * The primary diagnosis on admission was "acute exacerbation of chronic obstructive pulmonary disease, uncontrolled asthma, or acute exacerbation of bronchiectasis". Exclusion Criteria: * Patients were unable to undergo spirometry during the stabilization period; * Expected survival is less than 1 month; * Refusal to sign an informed consent form; * Chest imaging showed emerging patchy infiltrating shadows, lobar or segmental solid shadows, ground glass shadows, or interstitial changes with or without pleural effusion; * Patients with cystic fibrosis or with interstitial lung disease or other lung diseases with tractional branchial dilatation.

Primary outcome measure(s)

Length of hospital stay — From the date of admission until discharge or death, assessed over an estimated period of 3 to 30 days.
The length of time participants remain hospitalized from the date of admission to the date of discharge or death, whichever comes first.

Trial sites (9)

Facility	City	Region	Status
National Center for Respiratory Medicine, China-Japan Friendship Hospital	Beijing	Beijing Municipality	Recruiting
Zhujiang Hospital of Southern Medical University	Guangzhou	Guangdong	Recruiting
Henan Provincial People's Hospital	Zhengzhou	Henan	Recruiting
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	Wuhan	Hubei	Recruiting
The Second Xiangya Hospital of Central South University	Changsha	Hunan	Recruiting
The First Affiliated Hospital of China Medical University	Shenyang	Liaoning	Recruiting
The Second Affiliated Hospital of Xi'an Jiaotong University	Xi'an	Shaanxi	Recruiting
Ruijin Hospital Affiliated to Shanghai Jiao Tong University	Shanghai	Shanghai Municipality	Recruiting
West China Hospital of Sichuan University	Chengdu	Sichuan	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06798077 on ClinicalTrials.gov ↗ ← All trials in China