A Translational Study to Describe Clinical Characteristics, Biomarkers and to Identify Phenotypes and Endotypes Associated With Differential Outcomes in Chinese Population
A Translational Study to Describe Asthma Patient Clinical Characteristics, Treatment Patterns, Biomarkers and to Identify Phenotypes and Endotypes associated with Differential Outcomes that may Support Future Development of Personalised Treatment Strategies in Chinese Population
Eligibility
Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Age 18 to 75 years of age
* acceptable FEV1 (according to ATS and ERS)
* compliance with study procedures All Asthma Cohorts
* physician diagnosed Asthma greater or equal to 3 months prior to screening visit
Exclusion Criteria:
* history of alcohol or drug abuse within the past year
* pregnant at time of an assessment
* has an altered mental status at the time of informed consent
* receipt marketed or investigational biologic(s) within 3 months or 5 half-lives prior to visit 1, whichever is longer
* history or current upper or lower respiratory infection or symptoms within 2 weeks of baseline assessments
* terminal diseases and/or organ failure or participants otherwise considered not appropriate for the study participation
* Receipt LTRAs or 5-lipoxygenase (5-LO) inhibitors (eg zileuton and montelukast) within 1 month or 5 half-lives prior to baseline, whichever is longer.
Primary outcome measure(s)
Descriptive summary of demographic and subject characteristic, clinical characteristics and functional deliverables. — At baseline Descriptive summary of demographic and subject characteristic, clinical characteristics and functional deliverables at baseline by study cohorts.
Descriptive summary of biomarker level. — At baseline Descriptive summary of biomarker level at baseline by study cohorts.
Statistical clustering of key biomarkers. — At baseline Statistical clustering of key biomarkers in moderate to severe asthma cohort.
FEV1 level — At baseline Evaluation of lung function via airway limitation
Forced Vital Capacity (FVC) — At baseline Evaluation of lung function via airway limitation
Maximal Mid Expiratory Flow (MMEF) — At baseline Evaluation of lung function via airway limitation
Airway remodeling — At baseline Evaluation of lung structure profile and change
Gas trapping — At baseline Evaluation of lung structure profile and change
Computed Tomography (CT) Scan — At baseline Evaluation of lung structure profile and change
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time on our Cookie Policy page. See also our Privacy Policy.