Effect and Mechanism of Brain Stimulation for Parkinson's Disease With Cognitive Impairment

NCT06090682 · tracked via the Priya Life Science China tracker

Sponsor

Tianjin Huanhu Hospital

Phase

Observational

Started

2023-11-01

Last updated

2023-10-19

Condition(s) studied

Parkinson DiseaseCognitive Impairment

Investigational drug(s) / intervention(s)

Deep Brain Stimulation(DBS) and Transcranial Magnetic Stimulation(TMS)

Deep Brain Stimulation(DBS) and Transcranial Magnetic Stimulation(TMS): We observed the changes in cognitive function of patients before and after different brain stimulation treatments, and further compared the effects of different brain stimulation treatments on cognitive function of PD patients and the related mechanisms according to whether DBS surgery was performed or TMS therapy was given only according to the surgical indications.

Study summary

This study intends to apply structural and functional brain network neuroimaging techniques combined with image post-processing methods to explore the differences in brain network changes in PD patients with cognitive impairment after DBS or TMS.

Eligibility

Sex

ALL

Min age

—

Max age

75 Years

Healthy volunteers

Inclusion Criteria: 1\. The clinical diagnosis of PD is consistent with the United Kingdom Parkinson's Disease Society Brain Bank criteria, with disease duration over 5 years, acute levodopa motor response ≥30%, and indication for STN-DBS. Exclusion Criteria: Exclusion criteria included patients with severe cognitive impairment, severe psychiatric disorders, acute levodopa motor response less than 30%, atypical parkinsonism, and contraindications to surgery.

Primary outcome measure(s)

Montreal Cognitive Rating Scale(MoCA) — December 2023 to December 2026
The Montreal Cognitive Rating Scale was used to assess the overall cognitive status of patients before and after treatment
verbal fluency test (VF) — December 2023 to December 2026
VF test was used to assess frontal executive function and related language function

Trial sites (1)

Facility	City	Region	Status
Tianjin Huanhu Hospital	Tianjin	Tianjin Municipality	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06090682 on ClinicalTrials.gov ↗ ← All trials in China