Universal Chimeric Antigen Receptor T-Cell (UCAR T-cell) Therapy Targeting CD19/B Cell Maturation Antigen (CD19/BCMA) in Patients With r/r Neurological Autoimmune Diseases
Condition(s) studied
Investigational drug(s) / intervention(s)
UCAR T-cell: Universal allogeneic anti-CD19/BCMA CAR T-cells
Study summary
This is an open label, single-site, dose-escalation study in up to 12 participants with relapsed or refractory Neurological Autoimmune Diseases. This study aims to evaluate the safety and efficacy of the treatment with universal CD19/BCMA CAR T-cells.
Eligibility
Primary outcome measure(s)
- The number and severity of dose-limiting toxicity (DLT) events — Within 28 Days After UCAR T-cell Infusion
DLT will be graded according to the NCI Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0, and the ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells. - The total number, incidence, and severity of AEs — Up to 90 days After UCAR T-cell Infusion
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Tianjin Huanhu Hospital | Tianjin | China | Recruiting |
More Tianjin Huanhu Hospital trials in China
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06939166 on ClinicalTrials.gov ↗ ← All trials in China