The goal of this prospective observational research with an 8-year follow-up is to study the cognitive changes in the elderly in YuGarden community, Shanghai, China.
The main questions it aims to answer are:
* incidence of cognitive impairment in community (converting to mild cognitive impairment or Alzheimer's disease)
* to build a predictive model for the progression of cognitive impairment
Eligibility
Sex
ALL
Min age
60 Years
Max age
85 Years
Healthy volunteers
Accepted
Inclusion Criteria:
1. The participants are community-dwelling elderly people living in Yuyuan community, Shanghai, aged 60-85 years old, with no gender restriction.
2. Non-AD patients.
3. The participants can complete the cognitive tests, biological sample collection, speech tests, neuroimaging examinations, and cooperate with the implementation of the whole process of research.
4. The participants agree to participate in this study and sign the informed consent form.
Exclusion Criteria:
1. Participants who are suffering from severe mental illness, tumor cachexia, severe liver and kidney dysfunction and other serious physical diseases and unable to cooperate with the examination.
2. Participants who have visual or auditory impairment that hampers the completion of related examination.
3. Situations when magnetic resonance imaging or other examinations are contraindicated.
Primary outcome measure(s)
Incidence of cognitive impairment — 8 years Number of participants who covert to mild cognitive impairment (MCI) or AD will be recorded to calculate the incidence.
Trial sites (1)
Facility
City
Region
Status
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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