Study of Predictive Factors Related to Prognosis of Patients With Ischemic Stroke Due to Large-artery Atherosclerosis

Condition(s) studied

Investigational drug(s) / intervention(s)

carotid artery stenting: common treatments for carotid artery stenosis

carotid endarterectomy: common treatments for carotid artery stenosis

Aspirin: the dosage and duration

Clopidogrel: the dosage and duration

Anticoagulant: the dosage and duration

Statin: the dosage and duration

PCSK9 inhibitor: the dosage and duration

Study summary

This is a single-center prospective cohort study of predictive factors related to prognosis of ischemic stroke due to large-artery atherosclerosis.

From March 1, 2021 to December 31, 2026, 1000 patients with ischemic stroke due to large-artery atherosclerosis who are admitted to the Department of Neurology or Neurosurgery, Tongji Hospital are going to be recruited. Detailed clinical data in emergency room and in-hospital will be obtained from the medical record reviews, and the National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale (mRS) score will be done by certified neurologists to assess the severity of the disease in acute stage and treatment outcome during the follow-up. All cases will undergo routine blood tests, brain magnetic resonance imaging (MRI) and cerebral vascular examination, such as TCD, CTA, HRMR or DSA. The investigators will analyze the in-hospital factors that could predict the outcome to provide more evidence-based suggestions in the treatment and prognosis of atherosclerotic ischemic cerebrovascular disease.

Eligibility

Primary outcome measure(s)

• all-cause mortality — 3-6 months after onset.
  Death during the follow-up in every single reason
• Stroke of any kind — 3-6 months after onset.
  Brain CT or MRI scans will be used to measure whether there is any kind of stroke, including TIA, ischemic stroke, and hemorrhage

Trial sites (1)

On this site

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