Ambient Temperature and Thermoregulation During Exercise in Children and Youth

NCT07781605 · tracked via the Priya Life Science Canada tracker

Sponsor

University of Ottawa

Phase

Not applicable

Started

2026-07-19

Last updated

2026-08-24

Condition(s) studied

Body Temperature ChangesHeat StressChild DevelopmentHeatPhysiological Stress

Investigational drug(s) / intervention(s)

Exercise at 22°CExercise at 26°CExercise at 31°CExercise at 36°C

Exercise at 22°C: Participants complete intermittent exercise at a metabolic heat production of 160 W/m² in an ambient temperature of 22°C (72°F).

Exercise at 26°C: Participants complete intermittent exercise at a metabolic heat production of 160 W/m² in an ambient temperature of 26°C (79°F).

Exercise at 31°C: Participants complete intermittent exercise at a metabolic heat production of 160 W/m² in an ambient temperature of 31°C (88°F).

Exercise at 36°C: Participants complete intermittent exercise at a metabolic heat production of 160 W/m² in an ambient temperature of 36°C (97°F).

Study summary

Little is known about how children and youth regulate body temperature during exercise across different environmental temperatures compared with young adults, including whether differences in whole-body heat exchange contribute to their responses. The goal of this clinical trial is to determine how ambient temperature affects thermoregulation during exercise in boys and girls aged 9-16 years compared with young adult men and women aged 20-25 years. Participants will complete four study visits at ambient temperatures of 22°C (Celsius; 72°F, Fahrenheit), 26°C (79°F), 31°C (88°F), and 36°C (97°F), while exercising at the same moderate-intensity metabolic heat production of 160 W/m² (W = watts, m = meters). During each visit, participants will complete four 15-minute periods of exercise (exercise bouts 1, 2, 3 and 4 respectively) separated by 15-minute rest periods. Testing will be performed in a whole-body air calorimeter, a specialized chamber that precisely measures heat lost through evaporation and dry heat exchange and the amount of heat stored in the body. These measurements, together with core temperature and heart rate, will allow researchers to determine how increasing ambient temperature affects the body's ability to lose heat and whether these responses differ between children and youth and young adults.

Eligibility

Sex

ALL

Min age

9 Years

Max age

25 Years

Healthy volunteers

Accepted

Inclusion Criteria: * Healthy male or female. * Aged 9-16 years or 20-25 years. * Habitually active, defined as participating in regular physical activity at least 3 times per week for at least 20 minutes per session over the previous 6 months. * Able to understand and communicate in English or French. * For participants younger than 18 years, written parental or guardian consent and participant assent are required. Exclusion Criteria: * Acute illness at the time of testing (e.g., cold, flu, or infection). * History of a chronic medical condition that may affect thermoregulation, cardiovascular function, or exercise capacity (e.g., cardiovascular disease, metabolic disorders, respiratory disease including asthma requiring regular medication, or neurological disorders). * Use of medications known to affect thermoregulation, hydration status, or cardiovascular responses. * History of heat-related illness (e.g., heat exhaustion or heat stroke). * Digestive abnormalities or gastrointestinal conditions that may contraindicate ingestion of a telemetry pill. * Any condition that, in the opinion of the investigators, would compromise participant safety or the integrity of the data.

Primary outcome measure(s)

Core temperature — End of each of the four 15 minutes exercise bouts (average of last 5 minutes)
Core temperature indexed by visceral (telemetry pill) temperature

Trial sites (1)

Facility	City	Region	Status
University of Ottawa	Ottawa	Ontario	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07781605 on ClinicalTrials.gov ↗ ← All trials in Canada