Brain-based Prediction of the Dying Duration in Humans After Withdrawal of Life Sustaining Therapies to Inform Donation After Circulatory Death

Condition(s) studied

Study summary

The purpose of this study is to develop a new tool that uses information collected before life-sustaining treatments are withdrawn to better predict whether a patient will die within the time needed for organ donation to be possible. The tool created should help improve planning for organ donation and provide families and healthcare teams with more accurate information.

Eligibility

Primary outcome measure(s)

• To develop a clinically applicable model to predict dying duration in a cohort of patient eligible for donation after circulatory death — The models will be built to predict death within 30, 60 and 120 minutes
  Specifically, we aim at assessing the predictive ability of blood-based brain biomarkers, optic nerve sheet diameter as measured by head computed tomography (CT) scans as a surrogate of intracranial pressure and autonomic dysfunction as reflected by abnormal heart rate variability (HRV) to predict the dying duration.

Trial sites (11)

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