Prediabetes or DiabetesSurgery ComplicationsNon-Cardiac/ Non-Thoracic SurgeryStress Hyperglycemia
Study summary
The goal of this study is to measure the prevalence and risks of hyperglycemia in surgical patients with prediabetes. The main questions it aims to answer are:
* What is the prevalence of hyperglycemia in surgical patients with prediabetes?
* What is the relative risk of postoperative complications associated with hyperglycemia?
To answer these questions, surgical patients with prediabetes will undergo universal glucose measurement in the perioperative period. Glucose data will be analyzed in conjunction with electronic health record (EHR) data describing patient outcomes.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Hemoglobin A1c measurement between 6 and 6.4%
* Scheduled for non-cardiac surgery
Exclusion Criteria:
* Age\>18
* Pregnancy
* Any formal diabetes diagnosis
* Current use of medications that influence blood glucose regardless of the indication
* Undergoing cardiac, intracranial neurosurgery, bariatric, or pancreatic surgeries
Primary outcome measure(s)
Prevalence of perioperative hyperglycemia — Up to the first 3 postoperative days or discharge, whichever comes first. Prediabetes will be defined as described in Section 4.2 using Diabetes Canada definitions. The perioperative period will include the day of surgery and the early postoperative period. The day of surgery includes surgical admitting, intraoperative, and recovery room on postoperative day (POD) 0, which is the day that surgery was completed until 23:59. The early postoperative period will be defined as the first 3 full postoperative days, in keeping with studies that have demonstrated that hyperglycemia is most common in the first 72 hours after surgery and that early hyperglycemia is associated with greater 30-day postoperative mortality. Hyperglycemia will be defined using Diabetes Canada reference ranges as any glucose value \>10.0 mmol/L by any form of glucose measurement.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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