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Clinical Trials in Canada / NCT07220603
Recruiting Phase 2

An Open-Label Extension Study of PGN-EDODM1 in People With Myotonic Dystrophy Type 1 (FREEDOM-OLE)

NCT07220603 · tracked via the Priya Life Science Canada tracker
Sponsor
PepGen Inc
Phase
Phase 2
Started
2025-12-23
Last updated
2026-03-30

Condition(s) studied

Myotonic Dystrophy 1

Investigational drug(s) / intervention(s)

PGN-EDODM1 →

PGN-EDODM1: Administered by intravenous (IV) infusion

Study summary

The purpose of this study is to learn about the long-term safety and tolerability of PGN-EDODM1 in participants with myotonic dystrophy type 1 (DM1) who have completed a prior study with PGN-EDODM1.

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Participant has completed a prior study with PGN-EDODM1 Exclusion Criteria: * Abnormal laboratory tests at screening considered clinically significant by the Investigator * Use of an investigational drug (other than PGN-EDODM1), device, or product, within 30 days or 5 half-lives of the study drug (whichever is longer) prior to study entry

Primary outcome measure(s)

Trial sites (3)

FacilityCityRegionStatus
University of Calgary Calgary Alberta Recruiting
Ottawa Hospital Research Institute Ottawa Ontario Recruiting
CIUSSS du Saguenay-Lac-Saint-Jean Saguenay Canada Recruiting

More PepGen Inc trials in Canada

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07220603 on ClinicalTrials.gov ↗ ← All trials in Canada