Ketone Monoester (KME): 0.6 g KME per kg body mass; \[R\]-3-hydroxybutyl \[R\]-3-hydroxybutyrate. (Delta G Ketone, TΔS, Oxford).
Placebo: Inert, calorie-free placebo drink that is taste-matched to the ketone monoester supplement
Study summary
The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.
Eligibility
Sex
ALL
Min age
18 Years
Max age
35 Years
Healthy volunteers
Accepted
Inclusion Criteria:
\- Must be a member of the research expedition team travelling to the Barcroft Research Station in White Mountain California
Exclusion Criteria:
* BMI \> 30
* No prescribed medications (oral contraceptives excluded)
* History of smoking
* Currently following a ketogenic diet or consuming exogenous ketogenic supplements
* History of heart, lung, blood vessel, or kidney disease
* Currently pregnant
Primary outcome measure(s)
Cerebral Blood Velocity — 3 hours Transcranial Doppler ultrasound will be used to measure blood velocity in the middle cerebral artery and posterior cerebral artery. Location of measurements will remain consistent within participants.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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