🇮🇪Ireland
16°C Partly Cloudy · Dublin
Live Updates
--:--:-- IST
Contributor sign in
Latest
Clinical Trials in Canada / NCT06993233
Recruiting Phase 2

A Study With CIT-013 in HS Patients

NCT06993233 · tracked via the Priya Life Science Canada tracker
Sponsor
Phase
Phase 2
Started
2025-10-31
Last updated
2026-05-22

Condition(s) studied

Hidradenitis Suppurativa (HS)

Investigational drug(s) / intervention(s)

CIT-013 high dose →CIT-013 medium dose →Placebo

CIT-013 high dose: subcutaneous injection

CIT-013 medium dose: subcutaneous injection

Placebo: subcutaneous injection

Study summary

The goal of this clinical trial is to learn if CIT-013 works to treat Hidradenitis Suppurativa in adults. It will also learn about the safety of CIT-013. The main questions it aims to answer are:

Does CIT-013 lower the disease activity of HS patients? What medical problems do participants have when receiving CIT-013? Researchers will compare CIT-013 to a placebo (a look-alike substance that contains no drug) to see if CIT-013 works to treat the symptoms of HS.

Participants will:

Take receive 50 or 100 mg CIT-013 or placebo every other week for 12 weeks Visit the clinic once every 2 weeks for checkups and tests Keep monitor their symptoms during this period

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Male or female participants with HS of more than 6 months duration, * 18 years of age at screening visit, * Hidradenitis suppurativa lesions present in ≥ 2 distinct anatomic areas, one of which is Hurley Stage II or III (according to Hurley classification system), * A total abscess and inflammatory nodule (AN) count of ≥ 5 at screening and Day 1 prior to enrollment/randomization, * Participant must have had an inadequate response to oral antibiotics OR exhibited recurrence after discontinuation to, OR demonstrated intolerance to, OR have a contraindication to oral antibiotics for treatment of their HS, * Total draining tunnel count less than 20 Exclusion Criteria: \- Participants for whom an approved therapy with demonstrated clinical benefit is indicated, available and expected to be tolerated, OR choose to proceed with standard of care treatment options over the IP (after being appropriately informed of the treatment options, risks, and benefits). Any current and/or recurrent clinically significant skin condition in the treatment area other than HS, * Prior treatment with a recombinant therapeutic protein during the 6 weeks before baseline * Prior treatment with any of the following medications before baseline: 1. Any other systemic therapy for HS (28 days before baseline) 2. Any IV anti-infective therapy (14 days before baseline) * History of malignancy with exception of non-melanoma skin cancer that has been excised and cured,

Primary outcome measure(s)

Trial sites (28)

FacilityCityRegionStatus
CA-01 Barrie Canada Recruiting
CA-05 Calgary Canada Recruiting
CA-02 London Canada Recruiting
CA-04 Newmarket Canada Recruiting
CA-03 Winnipeg Canada Recruiting
DE-06 Bad Bentheim Germany Recruiting
DE-01 Bochum Germany Recruiting
DE-04 Dresden Germany Recruiting
DE-02 Frankfurt Germany Recruiting
DE-08 Kiel Germany Recruiting
DE-03 Oldenburg Germany Recruiting
Erasmus UMC Rotterdam Netherlands Recruiting
PL-06 Bialystok Poland Recruiting
PL-08 Gdansk Poland Recruiting
PL-03 Katowice Poland Recruiting
PL-02 Lodz Poland Not Yet Recruiting
PL-10 Lodz Poland Recruiting
PL-09 Poznan Poland Recruiting
PL-01 Rzeszów Poland Recruiting
PL-05 Wroclaw Poland Recruiting
ES-05 Barcelona Spain Not Yet Recruiting
ES-04 Madrid Spain Not Yet Recruiting
ES-02 Santiago de Compostela Spain Not Yet Recruiting
ES-03 Seville Spain Not Yet Recruiting
ES-01 Valencia Spain Recruiting
GB-02 Cardiff United Kingdom Recruiting
GB-05 Chester United Kingdom Recruiting
GB-04 London United Kingdom Recruiting

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06993233 on ClinicalTrials.gov ↗ ← All trials in Canada