Fasting + Exercise (FAST+EX): fasting + exercise condition: Participants will complete a 48-hour fast. One hour of exercise will be performed on each morning of the fast.
Fasting only (FAST): Non-exercise fasting condition: Participant will complete a 48-hour fast. No structured exercise will be performed during each of the fasting days.
Study summary
Many individuals engage in fasting for its purported health benefits but the effects of fasting on immune cell and whole body metabolism are not well understood in humans. Moreover, how exercising during a prolonged fast impacts immunometabolic outcomes is unclear. This study will determine how a 2 day fast - performed with or without daily exercise - impacts immune cell bioenergetics, immune cell function, and whole-body glycemic control in healthy active individuals.
Eligibility
Sex
ALL
Min age
19 Years
Max age
35 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Aged between 19 and 35 years.
* Physically active (engaging in ≥150 minutes of weekly moderate to vigorous physical activity).
Exclusion Criteria:
* History of cardiometabolic diseases or inflammatory diseases (e.g., chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, cardiovascular disease).
* Individuals currently following a ketogenic diet, low-calorie diet, periodic fasting regimen, or consuming ketogenic supplements (e.g., exogenous ketone drinks).
* Cigarette/vaping smoking.
* Physical limitation that will impair the ability of the participant to perform exercise.
* Individuals having a body mass index (BMI) over 30 kg/m2.
* Cancer diagnosis in the past 5 years.
* Taking anti-inflammatory drugs (e.g., ibuprofen, aspirin, naproxen).
* Being unable to read or communicate in English.
Primary outcome measure(s)
Monocyte mitochondrial respiration — Baseline and 48 hours Mitochondrial respiration will be measured in primary human monocytes using high resolution respirometry before and after a 48-hour fast performed with or without exercise.
Trial sites (1)
Facility
City
Region
Status
University of British Columbia Okanagan Campus
Kelowna
British Columbia
Recruiting
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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