Current recommendations for protein intake after bariatric surgery are not based on strong scientific evidence. It remains unclear how much protein should be eaten to minimize muscle loss and preserve the metabolism and function of individuals post-bariatric surgery.
The objective of this study is to analyze the relationships between changes in body composition, nutrition and protein intake, and muscle function after bariatric surgery to further our understanding of the nutritional needs of patients after bariatric surgery.
We intend to recruit around 75 participants, men and women, aged between 18 and 65 years. Participants will be recruited from the Bariatric Surgery Clinic, McGill University Health Center.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Male and female
* Aged 18 to 65 years old
* Undergoing first bariatric surgery (any type)
* Diabetics and non-diabetics
* Non-smokers and non-cannabis consumers
Exclusion Criteria:
* Pregnant and breastfeeding women
* Individuals undergoing second bariatric surgery
* Regular smokers and cannabis consumers
* Current use of Ozempic (or Ozempic-like medication) and anti-psychotic meds
* Limited physical mobility (using walking aids such as canes, walkers, or wheelchairs) and issues with hand resistance
* Kidney disease, non-controlled / unstable hypertension and hypothyroidism, and any metabolic disease other than diabetes
Primary outcome measure(s)
Change in weight — Baseline (pre-operation), and at 3-months and 6-months post-operation. Overall weight loss (kg)
Change in BMI — Baseline (pre-operation), and at 3-months and 6-months post-operation. Height and weight will be measured and combined to report BMI (kg/m\^2).
Change in fat mass — Baseline (pre-operation), and at 3-months and 6-months post-operation. Body composition is measured by dual-energy x-ray absorptiometry.
Change in overall body fat percentage — Baseline (pre-operation), and at 3-months and 6-months post-operation. Body composition is measured by dual-energy x-ray absorptiometry.
Resting Energy Expenditure — Baseline (pre-operation), and at 3-months and 6-months post-operation. Resting energy expenditure will be measured in a fasted state by indirect calorimetry. The volume of oxygen and carbon dioxide and water vapor pressure will be taken into consideration to calculate the resting energy expenditure.
Substrate Oxidation — Baseline (pre-operation), and at 3-months and 6-months post-operation. Substrate oxidation will be measured in a fasted state by indirect calorimetry. The volume of oxygen, carbon dioxide, and water vapor pressure will be taken into consideration to calculate the respiratory exchange ratio.
Nurition and Protein Intake — Baseline (pre-operation), and at 3-months and 6-months post-operation. A 3-day food journal and a 24-hour food recall will measure the nutritional profile (protein intake). A 24-hour urine sample will be used to measure urinary nitrogen concentration.
Hormone and Inflammatory Marker Assays — Baseline (pre-operation), and at 3-months and 6-months post-operation. The inflammatory cytokines, chemokines, and adipokines in blood will be measured using Enzyme-Linked Immunosorbent Assay (ELISA).
Trial sites (1)
Facility
City
Region
Status
Montreal General Hospital (MUHC)
Montreal
Quebec
Recruiting
More Concordia University, Montreal trials in Canada
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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