0 g Flax40 g whole ground flaxseed40 g roasted then ground whole flaxseed40 g of whole intact flaxseeds28 g flax hulls
0 g Flax: 175 g yogurt with no flax product
40 g whole ground flaxseed: 175 g yogurt with 40 g whole ground flaxseed
40 g roasted then ground whole flaxseed: 175 g yogurt with 40 g roasted then ground whole flaxseed
40 g of whole intact flaxseeds: 175 g yogurt with 40 g of whole intact flaxseeds
28 g flax hulls: 175 g yogurt with 28 g flax hulls
Study summary
A randomized, controlled, cross-over post-prandial trial in healthy human volunteers will be conducted at the IH Asper Institute to determine the effect whole ground flaxseed, roasted then ground whole flaxseed, whole intact flaxseed and flaxseed hulls mixed into yogurt on blood cyanide levels.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
1. Generally healthy adult, 18 years or older;
2. Willing to provide informed consent;
3. Willing/able to comply with the requirements of the study.
Exclusion Criteria:
1. Pregnant or lactating;
2. Medical history of disease that is currently under treatment;
3. Active treatment for any type of cancer within 1 year prior to study start;
4. Presence of a gastrointestinal disorder, daily use of any stomach acid-lowering medications or laxatives (including fibre supplements) within the past month or antibiotic use within the past 6 weeks;
5. Plasma concentration of vitamin B12 \< 148 pmol/L;
6. Complete blood count outside normal range;
7. Medical history of liver disease or liver dysfunction (defined as plasma AST or ALT ≥3 times the upper limit of normal (ULN));
8. Fasting blood glucose ≥6.1 mmol/L and/or HbA1c ≥6.0%;
9. Fasting plasma total cholesterol \>7.8 mmol/L;
10. Fasting plasma HDL \<0.9 mmol/L;
11. Fasting plasma LDL \>5.0 mmol/L;
12. Fasting plasma triglycerides \>2.3 mmol/L;
13. Systolic blood pressure \>140 mmHg or diastolic blood pressure \>90 mmHg;
14. Major surgery within the last 3 months;
15. Smoking, use of tobacco, vape or cannabis (within the last week);
16. Allergies to flaxseed or yogurt;
17. Aversion or unwillingness to eat study foods;
18. Participation in another clinical trial, current or in the past 4 weeks
Primary outcome measure(s)
Peak blood level of cyanide — 180 minutes highest concentration of cyanide during 180 min postprandial period
iAUC blood cyanide — 180 min incremental area under the curve for cyanide from 0-180 min
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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