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Clinical Trials in Canada / NCT06297226
Recruiting Phase 2

Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

NCT06297226 · tracked via the Priya Life Science Canada tracker
Phase
Phase 2
Started
2024-03-21
Last updated
2026-09-14

Condition(s) studied

Multiple Myeloma

Investigational drug(s) / intervention(s)

Arlocabtagene Autoleucel

Arlocabtagene Autoleucel: Specified dose on specified days

Study summary

The purpose of this study is to evaluate the effectiveness and safety of Arlocabtagene Autoleucel (BMS-986393) in participants with relapsed or refractory multiple myeloma.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria * Documented diagnosis of multiple myeloma (MM) as per International Myeloma Working Group (IMWG) criteria. * Received at least 4 classes of MM treatment \[including immunomodulatory drug (IMiD), proteasome inhibitor (PI), anti CD38 mAb, anti-BCMA therapy, and at least 3 prior lines of therapy (LOT). * Documented disease progression during or after their last anti-myeloma regimen as per IMWG 2016 criteria. * Participants must have measurable disease during screening. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Exclusion Criteria * Active or history of central nervous system involvement with MM. * Active systemic fungal, bacterial, viral, or other infection despite appropriate anti-infective treatment at the time of leukapheresis. Participants with severe infection, severe sepsis or bacteremia in the last 28 days prior to leukapheresis are excluded. * Received any prior therapy directed at G protein-coupled receptor class C, group 5, member D (GPRC5D) or has received other prior treatment for MM without the required washout prior to leukapheresis. * Other protocol-defined Inclusion/Exclusion criteria apply.

Primary outcome measure(s)

Trial sites (52)

FacilityCityRegionStatus
University of Alabama at Birmingham Birmingham Alabama Recruiting
Banner MD Anderson Cancer Center Gilbert Arizona Recruiting
University of Arkansas for Medical Sciences Little Rock Arkansas Recruiting
UCLA Hematology/Oncology - Westwood (Building 200 Suite 214) Los Angeles California Recruiting
UCSF Helen Diller Medical Center at Parnassus Heights San Francisco California Recruiting
Colorado Blood Cancer Institute Denver Colorado Recruiting
Mayo Clinic in Florida Jacksonville Florida Recruiting
Miami Cancer Institute at Baptist Health, Inc. Miami Florida Recruiting
Moffitt Cancer Center Tampa Florida Recruiting
Winship Cancer Institute of Emory University Atlanta Georgia Recruiting
Northside Hospital Atlanta Georgia Recruiting
Northwestern Memorial Hospital Chicago Illinois Recruiting
University of Chicago Medical Center Chicago Illinois Recruiting
University of Iowa Iowa City Iowa Recruiting
The University of Kansas Cancer Center - Westwood Westwood Kansas Recruiting
Norton Women's and Children's Hospital Louisville Kentucky Recruiting
Local Institution - 0065 Baltimore Maryland Withdrawn
Massachusetts General Hospital Boston Massachusetts Recruiting
Dana-Farber Cancer Institute Boston Massachusetts Recruiting
Mayo Clinic in Rochester, Minnesota Rochester Minnesota Recruiting
Washington University School of Medicine St Louis Missouri Recruiting
Rutgers Cancer Institute of New Jersey New Brunswick New Jersey Recruiting
Roswell Park Cancer Institute Buffalo New York Recruiting
Icahn School of Medicine at Mount Sinai New York New York Recruiting
Memorial Sloan Kettering Cancer Center New York New York Recruiting
University of North Carolina Medical Center Chapel Hill North Carolina Recruiting
Local Institution - 0067 Charlotte North Carolina Withdrawn
Oncology Hematology Care Cincinnati Ohio Recruiting
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center Columbus Ohio Recruiting
Oregon Health and Science University Portland Oregon Recruiting
Sidney Kimmel Cancer Center - Jefferson Health Philadelphia Pennsylvania Recruiting
Tennessee Oncology Nashville Tennessee Recruiting
Vanderbilt University Medical Center Nashville Tennessee Recruiting
Local Institution - 0069 Austin Texas Withdrawn
UT Southwestern Medical Center Dallas Texas Recruiting
University of Texas MD Anderson Cancer Center Houston Texas Recruiting
Methodist HealthCare System of San Antonio Clinical Trials Office, Texas Transplant Institute San Antonio Texas Recruiting
LDS Hospital Salt Lake City Utah Recruiting
Virginia Oncology Associates Norfolk Virginia Recruiting
Fred Hutchinson Cancer Center Seattle Washington Recruiting

+ 12 more sites — see the full list on the official registry below.

More Juno Therapeutics, Inc., a Bristol-Myers Squibb Company trials in Canada

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06297226 on ClinicalTrials.gov ↗ ← All trials in Canada