Vaping: Participants use their vaping products at their own discretion and their intake is monitored via questionnaires.
Study summary
This prospective study assesses the pulmonary and cardiovascular effets of vaping in adult electronic cigarette users with biannual visits and a 5-year follow-up.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
* Age 18 years or older
* Daily electronic cigarette user
* No respiratory infection in the 4 weeks before a visit
Exclusion Criteria:
* Women who are pregnant or breast-feeding.
Primary outcome measure(s)
Number of participants who vape daily with impaired lung volumes. — Every 6 months for 5 years Participants will perform plethysmography assessments to measure changes in lung volumes. Data will be expressed as a percentage of predicted values.
Number of participants who vape daily with impaired lung diffusion capacity. — Every 6 months for 5 years Participants will perform diffusion capacity of the lung for carbon monoxide (DLCO) measures to assess changes in lung diffusion capacity. Data will be expressed as a percentage of predicted values.
Number of participants who vape daily with impaired spirometry. — Every 6 months for 5 years Participants will perform spirometry tests measures to assess changes in forced expiratory lung volumes. Data will be expressed as a percentage of predicted values.
Number of participants who vape daily with airway hyperresponsiveness. — Every 6 months for 5 years Participants will perform methacholine provocation challenge measures to assess changes in airway hyperresponsiveness. Data will be expressed as the methacholine concentration inducing a fall of 20% of forced expiratory volume in the first second assessed (PC20).
Number of participants who vape daily with changes in blood cell count. — Every 6 months for 5 years Participants will perform a blood draw to assess blood cell count. Data will be expressed as a percentage of eosinophils, neutrophils, macrophages and lymphocytes of the total cell count.
Number of participants who vape daily with changes in sputum cell count. — Every 6 months for 5 years Participants will perform sputum inductions to assess cell count in the sputum. Data will be expressed as a percentage of eosinophils, neutrophils, macrophages and lymphocytes of the total cell count.
Vaping, tobacco and cannabis smoking habits of participants. — Every 3 months for 5 years Participants will complete questionnaires assessing their vaping habits, tobacco smoking and cannabis smoking history.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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