Predictors of Risk in Left Ventricular Non-Compaction

Condition(s) studied

Study summary

The goal of this study is to learn more about the risk factors associated with left ventricular non-compaction (LVNC) and the predictors of adverse outcomes associated with LVNC. The main questions this study aims to answer are as follows.

* Are there any genetic mutations that impact the risk of LVNC patients developing ventricular arrhythmias?
* Does LV myocardial strain increase risk stratification in the LVNC population with or without genetic mutations?
* What are some of the determinants that cause LV dysfunction in LVNC?
* What are other risk stratifiers (ex. premature ventricular contraction (PVC) burden on Holter, non-sustained ventricular tachycardia (NSVT) on stress test) that lead to an outcome of ICD implantation?

Participants will have their medical records accessed annually for a span of ten years, either prospectively or retrospectively depending on whether they are being actively followed by physicians at the Inherited Arrhythmia Clinic or not, to evaluate LVNC progression over time. This data will be stored in a large clinical registry with the London Heart Rhythm Program at the London Health Sciences Centre, University Hospital Campus.

Eligibility

Primary outcome measure(s)

• Develop a large clinical registry linked with the Inherited Arrhythmia Clinic — Up to 10 years
  The Inherited Arrhythmia Clinic is a subdivision of the London Heart Rhythm Program at University Hospital, London Health Sciences Centre. As such, data will not go offsite but will simply be stored in a local REDCap database.

Trial sites (1)

More London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's trials in Canada