Magnetic Resonance Imaging (MRI): Combined orbital and cranial vessel wall MRI
Study summary
The research study is being conducted to determine the utility of magnetic resonance imaging (MRI) in identifying inflammation of arteries supplying blood to the head, brain, and eyes. The target population includes patient with suspected giant cell arteritis (GCA; temporal arteritis).
Eligibility
Sex
ALL
Min age
50 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
* Age 50 years or older
* First presentation of suspected GCA
* New or worsening cranial manifestations within 4 weeks of enrollment concerning for active GCA
* Elevated CRP greater than 1.0 mg/dl
* Plan to undergo temporal artery biopsy or ultrasound for diagnosis
Exclusion Criteria:
* Contra-indication to receiving MRI including:
Implanted medical devices, pacemaker, and metallic foreign fragments inside body/orbits Known gadolinium allergy Women who are pregnant or nursing
* Absence of cranial symptoms related to GCA (e.g., only large vessel GCA)
Primary outcome measure(s)
Vessel Wall Enhancement Score — Up to 12 months Enhancement of cranial vessel wall, orbital structures, or other cranial structures. Scores range from 0 to 3; 0 being no inflammation and 3 being more enhancement or inflammation.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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