Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

Condition(s) studied

Investigational drug(s) / intervention(s)

0.9% Sodium Chloride Injection: All participants will be injected subcutaneously with a single 0.5ml dose

Lidocaine Injection 2%: All participants will be injected subcutaneously with a single 0.5ml dose

Study summary

Local anesthetic resistance is commonly reported by patients with EDS. However, there are no objective data on the occurrence of local anesthetic resistance in EDS patients and in healthy volunteers. The investigators propose to collect such objective data on the frequency of drug resistance and whether any problems with local anesthesia are due to initial ineffectiveness or due to its effects dissipating too soon.

Eligibility

Primary outcome measure(s)

• Delta Pain Scores Lidocaine at 5 min [ Time Frame: 5 minutes post-injection ] — 5 minutes post-injection
  Difference between the pain score at the Lidocaine injection locations (compared to a control location) and the saline injection location (compared to a control location). The pain scale is .a 4 level scale from 0 ("absent sensation"), to 1 ("dull pressure"), to 2 ("sharp but less than a control \[non-injected\] region) to 3 (same or worse than the control region).

Trial sites (1)

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