Pharmacogenetic Supported Prescribing in Kids

NCT04797364 · tracked via the Priya Life Science Canada tracker

Sponsor

University of Calgary

Phase

Not applicable

Started

2021-01-18

Last updated

2026-05-12

Condition(s) studied

Mental Health Impairment

Investigational drug(s) / intervention(s)

Pharmacogenetic Testing

Pharmacogenetic Testing: Participants will donate a 2ml (teaspoon) sample of saliva. DNA extracted from the saliva sample will be used for genotyping. Genotyping results will be translated into an interpretative clinical report using evidence-based software (Sequence2Script) developed by our group and delivered to the treating physician for use in their clinical decision-making. The report will contain genotyping results, predicted phenotype, and evidence-based drug selection and dosing recommendations relevant to the child's current and future care

Study summary

Implementation of pharmacogenetic testing for children and adolescents aged 6-24 who are starting or changing psychiatric medication.

Eligibility

Sex

ALL

Min age

6 Years

Max age

24 Years

Healthy volunteers

Inclusion Criteria: * Medical records available * The initiation, change, dose adjustment, or augmentation of psychiatric medication(s) is indicated * Treating psychiatrist, family physician, or pediatrician licensed in Alberta, British Columbia, Saskatchewan, or Manitoba requests pharmacogenetic testing Exclusion Criteria: * Medically unstable or lacking capacity to provided informed consent * Unwillingness of child to provide saliva sample for genetic analysis * History of liver or bone marrow (hematopoietic cell) transplant

Primary outcome measure(s)

Adverse drug reactions — 6-months
Relative change in adverse drug reaction frequency
Symptom severity — 6-months
Relative change in symptom severity

Trial sites (1)

Facility	City	Region	Status
University of Calgary	Calgary	Alberta

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04797364 on ClinicalTrials.gov ↗ ← All trials in Canada