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Clinical Trials in Canada / NCT04767074
Recruiting Not applicable

A Non-pharmacological Cough Control Therapy

NCT04767074 · tracked via the Priya Life Science Canada tracker
Phase
Not applicable
Started
2020-09-01
Last updated
2025-04-03

Condition(s) studied

CoughILDPulmonary DiseasePulmonary Fibrosis

Investigational drug(s) / intervention(s)

Non-pharmacological Cough control Therapy

Non-pharmacological Cough control Therapy: Participants will attend four virtual sessions of 45 to 60 minutes of educational and self-management. Session 1 General assessment Prescription and taught of one cough suppression technique. Session 2 Cough principles: mechanism, cough reflex, chronic cough, the importance of cough and negative effects of repeated coughing. Cough control: identify triggers, use cough suppressions and distractions techniques. Session 3 Breathing pattern retraining and laryngeal hygiene: reinforce nasal breathing and pursed lips breathing as strategies to avoid the urge to cough, identification of risk factors for laryngeal dehydration and hydration education. Session 4 Reinforcement: Clarification of doubts, techniques' reinforcement and application during daily life situations.

Study summary

Coughing affects almost all individuals with ILD leading to physical, psychological and social distress and prevents individuals from performing their activities of daily living, working or socialising in public places. Unfortunately, there are no licensed medications available to treat chronic cough and the few drugs that have been tried resulted in little efficacy and significant side effects. Drug-free cough control interventions have shown promise in reducing the severity and impact of coughing on patients' lives but have not been tested in individuals with ILD. This study aims to explore the feasibility and effectiveness of a non-pharmacological cough control therapy, as an adjuvant of pulmonary rehabilitation, in patients with ILD and chronic cough (\>8 weeks in duration).

Eligibility

Sex
ALL
Min age
18 Years
Max age
85 Years
Healthy volunteers
No
Inclusion Criteria: * Individuals will be included if having confirmed diagnosis of any ILD by a physician (as per Canadian Thoracic Society's guideline for evaluating patients with fibrotic interstitial lung disease) and a chronic cough lasting more than 8 weeks in duration Exclusion Criteria: * self-reports of moderate or large sputum production * effective or suspected exacerbation of the respiratory condition in the past month * upper respiratory tract infection in the past month * use of angiotensin-converting enzyme inhibitor medication * changes in the prescribed medication in the previous month * evidence of traction bronchiectasis in the HRCT * evidence of other medical conditions that prevent performance of an exercise training program * unable to read or speak in English / unable to provide informed consent.

Primary outcome measure(s)

Trial sites (2)

FacilityCityRegionStatus
St. Joseph's Healthcare Hamilton Hamilton Ontario Recruiting
West Park Healthcare Centre Toronto Ontario Recruiting

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Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04767074 on ClinicalTrials.gov ↗ ← All trials in Canada