Electrophysiological Pacing: Assess the MCA CBF velocity response at different paced heart rates.
Study summary
The investigators will seek to determine the relationship between heart rate and middle cerebral artery (MCA) cerebral blood flow (CBF), as well as better understand the hemodynamic determinants of MCA CBF velocity. In order to manipulate heart rate, the investigators will recruit patients already scheduled for clinically indicated elective electrophysiological studies, where temporary pacing catheters placed in the right atrium can be used to artificially pace the heart at controlled rates. MCA CBF will be measured by transcranial Doppler ultrasound.
Eligibility
Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
No
Inclusion Criteria:
* Male or female
* Age 18-70 years, inclusive
* Scheduled for clinically indicated elective electrophysiological studies where temporary pacing catheters are being placed in the right atrium
* Left ventricular ejection fraction ≥50%
* Able and willing to provide informed consent
* Able to travel to the Cardiac Electrophysiology Laboratory at the Foothills Medical Centre, Calgary, Alberta, Canada
Exclusion Criteria:
* Unable or unwilling to provide informed consent
* Other factors which in the investigator's opinion would prevent the participant from completing the protocol
Primary outcome measure(s)
Change in MCA CBF velocity in response to high right atrial pacing at 400 ms (150 bpm) relative to baseline while in the supine position — After 1 minute of pacing at 400 ms (150 bpm) Compare the MCA CBF velocity at the participant's own baseline sinus rhythm (\<100 bpm) and during pacing at 400 ms (150 bpm)
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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