Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates

Condition(s) studied

Investigational drug(s) / intervention(s)

Pacing: Assess the non-invasively determined stroke volume and cardiac output response at different paced heart rates in patients with a cardiac pacemaker or implanted defibrillator with preserved ejection fractions (LVEF≥50%)

Study summary

The investigators will seek to determine the effects of different heart rates on both stroke volume and cardiac output using non-invasive hemodynamic assessments. In order to safely manipulate the HR, the investigators will study patients with permanent pacemakers in whom heart rate manipulation can be done in a safe and non-invasive manner.

Eligibility

Primary outcome measure(s)

• Change in cardiac output while atrial pacing at lower and higher rates while supine — 1 day
  Change in cardiac output (CO) when atrial pacing at 80 bpm \& 120 bpm while supine. CO = HR x Stroke volume (SV)

Trial sites (1)

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