High-Intensity Progressive Inspiratory Muscle Training in Class III Obesity and Obstructive Sleep Apnea

Condition(s) studied

Investigational drug(s) / intervention(s)

High-Intensity Progressive Inspiratory Muscle Training (IMT): "The intervention consists of 12 weeks of inspiratory muscle training performed 5 days per week. Each session includes 30 breaths through a resistive loading device (POWERbreathe). The training intensity starts at 40% of the Maximum Inspiratory Pressure (MIP) and progressively increases to 90% of MIP. Training load is adjusted weekly based on new MIP measurements to ensure high-intensity stimulus. Compliance and adverse events will be monitored through a training diary."

Study summary

The purpose of this study is to evaluate the feasibility and effects of a 12-week high-intensity progressive Inspiratory Muscle Training (IMT) program in individuals with Class III obesity (BMI ≥ 40 kg/m²) and obstructive sleep apnea (OSA). Using a single-case experimental design (SCED) with multiple baselines, the study will investigate whether this respiratory intervention can reduce the severity of sleep apnea, as measured by the Apnea-Hypopnea Index (AHI), and improve inspiratory muscle strength and sleep quality. Participants will perform daily training sessions using a resistive loading device (POWERbreathe), with intensity progressing from 40% to 90% of their maximum inspiratory pressure.

Eligibility

Primary outcome measure(s)

• Apnea-Hypopnea Index (AHI) — Baseline (Phase A - three measurements) and Post-Intervention (Phase B - 12th week).
  Number of apnea and hypopnea events per hour of sleep, measured via portable polygraphy (Type III)

Trial sites (1)

More University of the State of Santa Catarina trials in Brazil

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