Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)

NCT05246813 · tracked via the Priya Life Science Belgium tracker

Sponsor

Imelda Hospital, Bonheiden

Phase

Observational

Started

2022-02-11

Last updated

2026-03-25

Condition(s) studied

OsteoporosisOsteoarthritis, HipHip FracturesClonal Hematopoiesis of Indeterminate PotentialAging

Investigational drug(s) / intervention(s)

Blood and bone marrow cell collection

Blood and bone marrow cell collection: Collection of blood and bone marrow

Study summary

Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations. Combined single-cell transcriptomics and mutation-specific single-cell genotyping (biotin-PCR using mutation-targeted primers followed by sequencing) will subsequently be performed. The gene expression profile of wildtype and mutant hematopoietic stem cells will be compared, performing both broad gene set enrichment analysis and targeted analysis of metabolic pathways.

Eligibility

Sex

ALL

Min age

55 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age 65 years and older Exclusion Criteria: * known haematological condition (myelodysplasia, leukemia, cancer) * inability to provide written informed consent

Primary outcome measure(s)

Gene Set Enrichment Analysis (GSEA) Normalized Enrichment Score (NES) — One day

Trial sites (1)

Facility	City	Region	Status
Imelda Hospital	Bonheiden	België	Recruiting

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Other trials for the same condition

RECONFIRM - Study of AGN1 LOEP in Patients with Osteoporosis Recruiting

HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial Recruiting

RESTORE - Study of AGN1 LOEP to Prevent Secondary Hip Fractures Recruiting

CONFIRM EXTENSION - Long-term Follow-up Study of Patients Treated with AGN1 LOEP Active, not recruiting

PMCF Study on the Safety and Performance of the Zimmer® Maxera™ Acetabular System in Total Hip Arthroplasty Active, not recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05246813 on ClinicalTrials.gov ↗ ← All trials in Belgium