Quantitative Net Water Uptake as a Predictor of Functional Outcomes After Intravenous Thrombolysis in Acute Ischemic Stroke International Multicenter Observational Retrospective Study

NCT07299981 · tracked via the Priya Life Science Austria tracker

Sponsor

Sigmund Freud PrivatUniversitat

Phase

Observational

Started

2026-02-01

Last updated

2026-07-16

Condition(s) studied

Ischemic StrokeThrombolysis

Investigational drug(s) / intervention(s)

No Interventions

No Interventions: Not applicable as this is an observational, retrospective study.

Study summary

While the effectiveness of intravenous thrombolysis (IVT) decreases over time, patients show considerable variability in how quickly their ischemic core progresses. Quantitative net water uptake (NWU) has emerged as a biomarker indicating blood-brain barrier disruption and may better reflect the "tissue clock" than time alone. Low NWU is associated with favorable outcomes, whereas high NWU predicts poor outcomes and futile recanalization. The study aims to determine whether NWU measured on initial non-contrast CT is a treatment effect modifier for the IVT therapy.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Acute ischemic stroke treated with intravenous thrombolysis * Imaging with non-contrast cranial CT on admission * Follow-up imaging with non-contrast cranial CT or MRI 12-24 hours after IVT * Final Infarct volume \> 5ml * ASPECTS available Exclusion Criteria: * Known use of oral anticoagulation (OAC) on admission * Preexisting ischemic infarction on admission non-contrast cranial CT * Patients with large vessel occlusion AIS who underwent mechanical thrombectomy * Low imaging quality precluding radiological measurements * Severe white matter lesions precluding radiological measurements * No ASPECTS

Primary outcome measure(s)

Number of participants with functional independence (modified Rankin Scale score 0-1) — at 90 days
Functional independence defined as a modified Rankin Scale (mRS) score of 0-1 assessed at 90 days.

Trial sites (1)

Facility	City	Region	Status
Department of Neurology, St. John's Hospital, Vienna, Austria, Vienna, 1020	Vienna	Austria	Recruiting

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Other trials for the same condition

Stroke-Card Registry Active, not recruiting

Safety and Efficacy of Intravenous Thrombolysis in Patients With Ischemic Stroke and Direct Oral Anticoagulants Intake Recruiting

Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants Recruiting

Efficacy and Safety of Intravenous Thrombolysis in Branch Atheromatous Disease Recruiting

Reperfusion Injury After Endovascular Stroke Treatment Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07299981 on ClinicalTrials.gov ↗ ← All trials in Austria