AGMT Austrian Lymphoma Registry

Condition(s) studied

Study summary

Lymphomas are a group of cancers that originate in the lymphatic system, a key component of the immune system. They can be broadly categorized into two main types: Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL).

There are different subtypes of HL, including classical Hodgkin lymphoma (cHL) and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). The subtypes of cHL include nodular sclerosis, mixed cellularity, lymphocyte-rich, and lymphocyte-depleted.

Non-Hodgkin lymphomas are more diverse and comprise a wide range of subtypes, each with distinct genetic, molecular, and clinical features. Common subtypes of NHL include Diffuse large B-cell lymphoma (DLBCL), Follicular lymphoma (FL), Mantle cell lymphoma (MCL), Chronic lymphocytic leukemia (CLL), myeloma, and other rarer subgroups.

Many of these diseases typically present with lymph node enlargement, bone marrow infiltration, general and lymphoma subtype specific symptoms and laboratory abnormalities.

Novel agents have improved the prognosis of high-risk lymphoma patients in the front-line and relapsed setting and more accurate prognostic tools enable less intensive treatment for low-risk patients, while maintaining their good prognosis.

Lymphoma disease have not been systematically assessed in Austria to date. This medical registry of the AGMT is thus the first Austrian-wide standardized documentation of epidemiology, clinical course and molecular and other biologic data of this disease. As lymphomas are a very heterogeneous group, not all subtypes will always be documented simultaneously in this registry. Which lymphoma subtype is to be documented can change over time, depending on which clinical question is currently in focus.

Eligibility

Primary outcome measure(s)

• General Characteristics — 10 years
  To describe general characteristics of lymphoma patients
• Genetic Profiling — 10 years
  To describe genetic risk profiles
• Proportion of lymphoma patients in Austria that require treatment — 10 years
  To describe the proportion of lymphoma patients in Austria that require treatment
• Proportion of lymphoma patients in Austria under active surveillance — 10 years
  To describe the proportion of lymphoma patients in Austria under active surveillance
• Number of patients with concomitant diseases — 10 years
  To describe concomitant diseases at diagnosis of lymphoma
• Number of treatment and outcome of treatment — 10 years
  To describe treatment and outcome of treatment, among them * historical standard with immunochemotherapy * cellular therapies (e.g. Car-T cells) * novel immunotherapies such as bispecific antibodies * continuous treatment or an induction/maintenance approach * sequence of use of various treatments * treatment duration * treatment adjustments * frequency and degree of response
• Patient Outcome — 10 years
  To describe patient's outcome
• Toxicities — 10 years
  To describe toxicity with a focus on immunological mediated side effects of treatment (e.g. Cytokine release syndrome (CRS), Immune effector cell-associated neurotoxicity syndrome (ICAN) etc.)

Trial sites (1)

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