thrombelastogram: Patients in the TEG group will receive prothrombin complex concentrates (PCC) at a dose of 10 IE/kg of ideal body weight, when R-time was greater than 40 minutes (2400 sec) and they will receive platelet transfusion in the amount of 1 apheresis unit when MA was below 30 mm
standard of care: 2\) In the SOC group, patients will receive PCC at the dose of 10 IE /kg of ideal body weight when the PT is below 50% and/or INR\>1.8 and/or received platelet transfusion in the amount of 1 apheresis when platelet count is below 50 G/L
Study summary
Assess whether a pre-interventional thrombelastography guided algorithm for assessing and correction of coagulation status in cirrhotic patients is safe and effective
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
inclusion criteria
* Liver cirrhosis
* \>18 years
* Indication for TIPS implantation
* Ability to sign informed consent exclusion criteria
* Contraindications against TIPS implantation
* Hepatocellular carcinoma BCLC D
* Ongoing bleeding
* pre-existing anticoagulant therapy at time of inclusion
* administration of blood products within 1 week prior to the enrolment
* Other malignancies that lead to an impaired 90-day survival
* Inherit blood clotting disorders
* Hepatic encephalopathy grade 3 or 4
* any other condition or circumstance, which, in the opinion of the investigator, would affect the patient's ability to participate in the protocol
Primary outcome measure(s)
blood product requirement — 2 days Amount of blood products (coagulation factors and platelet transfusions) transfused for pre-interventional correction of coagulation status
Trial sites (1)
Facility
City
Region
Status
Department of Internal Medicine, Medical University of Graz
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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