The CPR, Pre-hospital ECPR and Early Reperfusion Study: A Target Trial Emulation

NCT07679737 · tracked via the Priya Life Science Australia tracker

Sponsor

Australian and New Zealand Intensive Care Research Centre

Phase

Observational

Started

2025-01-01

Last updated

2026-07-01

Condition(s) studied

Out of Hospital Cardiac ArrestExtracorporeal Cardiopulmonary Resuscitation

Investigational drug(s) / intervention(s)

Extracorporeal cardiopulmonary resuscitation

Extracorporeal cardiopulmonary resuscitation: The Intervention being evaluated is the initiation of extracorporeal cardiopulmonary resuscitation (ECPR) at the scene, in addition to conventional cardiac arrest care.

Study summary

CHEER4TTE is a target trial emulation, designed to simulate a randomised controlled trial by utilising data from pre-existing data sources. The aim is to determine whether prehospital ECPR for refractory out-of-hospital cardiac arrest improves the rate of survival to hospital discharge when compared to conventional cardiac arrest care.

Eligibility

Sex

ALL

Min age

18 Years

Max age

70 Years

Healthy volunteers

Inclusion Criteria: * Witnessed cardiac arrest * Bystander CPR * Refractory cardiac arrest (failure to achieve sustained ROSC \>20 minutes) * Initial cardiac rhythm VF, VT or PEA * Within the hours of prehospital ECPR service operation Exclusion Criteria: * Initial cardiac rhythm asystole * ROSC with sustained recovery * Unable to reach the patient and commence cannulation within 45 minutes of onset of arrest * Evidence of/suspected end-stage disease: * severe disability impairing activities of daily living * end-stage organ disease - cardiac, liver, lung, renal * other life-limiting diseases, e.g. malignancy, terminal illness * advance health care directive * Time periods of advanced public health restrictions in Victoria and NSW due to COVID-19

Primary outcome measure(s)

Survival to hospital discharge — From meeting full eligibility criteria until the date/time of death or hospital discharge, assessed up to 180 days

Trial sites (1)

Facility	City	Region	Status
Monash University	Melbourne	Victoria

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07679737 on ClinicalTrials.gov ↗ ← All trials in Australia