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Clinical Trials in Australia / NCT05135052
Active, not recruiting Not applicable

Rhenium-Skin Cancer Therapy (SCT) for the Treatment of Non-Melanoma Skin Cancer.

NCT05135052 · tracked via the Priya Life Science Australia tracker
Sponsor
OncoBeta Therapeutics
Phase
Not applicable
Started
2022-01-17
Last updated
2025-05-14

Condition(s) studied

Non-melanoma Skin Cancer

Investigational drug(s) / intervention(s)

Rhenium-SCT

Rhenium-SCT: Rhenium-SCT irradiation device

Study summary

Efficacy of Personalised Irradiation with Rhenium-Skin Cancer Therapy (SCT) for the treatment of non-melanoma skin cancer; a phase IV multi-centre, international, open label, single arm study.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: 1. Stage I or II BCC or SCC (SCC Well to Moderately Differentiated), and clinically node negative disease 2. Confirmed Histology, and with depth of lesion noted 3. Subjects with up to 3 lesions suitable to enter the study (subjects with more than 3 lesions are not excluded from the study, however 3 target lesions are determined for study evaluation only.) 4. Subjects able and willing to comply with the requirements of the study 5. Age \>=18 years 6. Informed Consent signed by the subject consenting to undergo the study 7. Lesions up to 8cm2 8. Lesions with a depth up to 3mm confirmed on biopsy report AND deemed appropriate clinically by treating clinician 9. Subjects who are not deemed suitable for surgery, for example due to tumour location, performance status or other comorbidities as deemed relevant by the treating clinician 10. Patients who may have declined Surgery and/or fractionated Radiation Therapy Exclusion Criteria: 1. Inability to personally provide written informed consent or to understand and collaborate throughout the study 2. Inability or unwillingness to comply with study requirements 3. Prior treatment with surgery or radiation therapy for their target lesion(s) 4. Depth of lesion greater than 3mm as defined by Biopsy and/or clinical assessment 5. Lupus and Scleroderma 6. Basal cell naevus syndrome, xeroderma, vitiligo and albinism 7. Prior laser at the tumour site 8. Malignant melanoma systemic therapy ongoing 9. Any ongoing treatment for malignancy, or in the last 4 weeks prior to study entry 10. A tumour affecting nerves or bony structures 11. Clinical concern of metastatic disease 12. Pregnancy and/or Lactation 13. Pathological exclusions: Perineural Invasion, Lymphovascular invasion 14. Anatomical exclusions: NMSC's of the Medial canthus, eyelid margin (upper and lower), Vermillion lip

Primary outcome measure(s)

Trial sites (7)

FacilityCityRegionStatus
Genesis Care Health Hub at RNS Sydney New South Wales
John Flynn Hospital Tugun Queensland
Hollywood Private Perth Western Australia
Klinik Ottakring Ottakring Austria
Rostock University Hospital Rostock Germany
Steve Beko Hospital Pretoria South Africa
Kings College Hospital London London United Kingdom

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05135052 on ClinicalTrials.gov ↗ ← All trials in Australia