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Neurocrine Biosciences clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine and the EU Clinical Trials Information System (CTIS) — current trials in our USA, UK and EU (CTIS) registers with Neurocrine Biosciences as lead sponsor. Synced 26 Sep 2026
19Current trials
13Recruiting now
3Drugs in these trials
3Trial registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from ClinicalTrials.gov and CTIS registry records · Last verified · Editorial standards
At a glance

Neurocrine Biosciences is the lead sponsor of 19 current clinical trials in our USA, UK and EU (CTIS) registers. 13 are recruiting patients now. The most common phase is Phase 3. The drugs named most often in its trials are NBI-1117568, NBI-1065845 and Crinecerfont. The most-studied condition is Major Depressive Disorder.

ClinicalTrials.gov trials by status

  • Recruiting1387%
  • Active, closed213%

Trials by phase

  • Phase 31173%
  • Phase 2320%
  • Phase 417%
01

Clinical trials sponsored by Neurocrine Biosciences

15 on ClinicalTrials.gov
StudyPhaseStatusStartRegisters
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
NCT06963021 · ClinicalTrials.gov ↗ · Major Depressive Disorder
Phase 3 Recruiting 2025-05 UK, USA
Evaluation of NBI-1117570 in Inpatient Adults With Schizophrenia
NCT07288333 · ClinicalTrials.gov ↗ · Schizophrenia
Phase 2 Recruiting 2026-02 UK
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
NCT06966401 · ClinicalTrials.gov ↗ · Major Depressive Disorder
Phase 3 Recruiting 2025-04 UK, USA
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
NCT07105111 · ClinicalTrials.gov ↗ · Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
Phase 4 Recruiting 2025-08 USA
Efficacy, Safety, and Tolerability of NBI-1065890 Versus Placebo in Adults With Tardive Dyskinesia
NCT07365462 · ClinicalTrials.gov ↗ · Tardive Dyskinesia
Phase 2 Recruiting 2026-02 USA
NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
NCT06911112 · ClinicalTrials.gov ↗ · Major Depressive Disorder
Phase 3 Recruiting 2025-03 USA
Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
NCT06786624 · ClinicalTrials.gov ↗ · Major Depressive Disorder
Phase 3 Recruiting 2025-01 USA
An Assessment of Efficacy, Safety, and Pharmacokinetics of NBI-1117568 in Adults With Bipolar I Disorder With Current Mania
NCT07288320 · ClinicalTrials.gov ↗ · Bipolar I Disorder, Mania
Phase 2 Recruiting 2025-12 USA
NBI-1117568-SCZ3029: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia
NCT06963034 · ClinicalTrials.gov ↗ · Schizophrenia
Phase 3 Recruiting 2025-05 USA
NBI-1117568-SCZ3030: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia
NCT07105098 · ClinicalTrials.gov ↗ · Schizophrenia
Phase 3 Recruiting 2025-08 USA
Efficacy of NBI-1117568 in Preventing Relapse in Adults With Schizophrenia
NCT07227818 · ClinicalTrials.gov ↗ · Schizophrenia
Phase 3 Recruiting 2025-12 USA
A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
NCT07196501 · ClinicalTrials.gov ↗ · Major Depressive Disorder
Phase 3 Recruiting 2025-08 USA
NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia
NCT07114874 · ClinicalTrials.gov ↗ · Schizophrenia
Phase 3 Recruiting 2025-07 USA
Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia
NCT04490915 · ClinicalTrials.gov ↗ · Congenital Adrenal Hyperplasia
Phase 3 Active, closed 2020-12 UK, USA
Global Safety and Efficacy Registration Study of Crinecerfont in Pediatric Participants With Classic Congenital Adrenal Hyperplasia (CAHtalyst Pediatric Study)
NCT04806451 · ClinicalTrials.gov ↗ · Congenital Adrenal Hyperplasia
Phase 3 Active, closed 2021-06 UK, USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Titles and statuses are copied from the registry as published.

02

Neurocrine Biosciences in the EU trials register (CTIS)

4 trials

Authorised or ongoing trials in the EU Clinical Trials Information System with Neurocrine Biosciences as sponsor. Some are the same study as a ClinicalTrials.gov record above; the two registries share no common ID. Trials with a site in Ireland are listed first.

StudyPhaseStatusCountries
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, and Tolerability of NBI-1065890 in Adult Participants With Tardive Dyskinesia
2025-524104-30-00 · Nervous System Diseases
Phase 2 Ongoing Bulgaria, Croatia, Romania + 2 more
A Phase 3b, Open-Label Study of Crinecerfont to Evaluate Androgen Reduction and Related Outcomes in Adults With Classic Congenital Adrenal Hyperplasia
2025-524282-24-00 · Hormonal diseases
Phase 3 Authorised Czechia, Germany, Sweden + 6 more
A Phase 2a, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of NBI-1117570 in Adults with Schizophrenia Who Warrant Inpatient Hospitalization
2025-521868-35-00 · CTIS ↗ · Mental Disorders
Phase 2 Ongoing Romania, Poland, Bulgaria + 1 more
A Global, Phase 3, Multicenter, Open-Label Study to Assess the Long-Term Safety and Tolerability of NBI-1117568 in Adults with Schizophrenia
2025-521216-19-00 · CTIS ↗ · Mental Disorders
Phase 3 Ongoing Romania, Hungary, Bulgaria
03

Drugs in Neurocrine Biosciences trials

3 compounds

Drugs and biologicals named as interventions in these trials, with the number of this sponsor's trials that name each one. Placebos and generic comparators are excluded.

04

Conditions in Neurocrine Biosciences trials

8 conditions
Major Depressive Disorder6Schizophrenia6Congenital Adrenal Hyperplasia2Schizoaffective Disorder1Bipolar Disorder1Tardive Dyskinesia1Bipolar I Disorder1Mania1
05

By trial register

RegisterTrialsRecruiting
Clinical trials in USA1412
Clinical trials in UK53
EU register (CTIS)4—

A trial with sites in more than one country appears in each of those registers.

06

Other sponsors in Major Depressive Disorder

SponsorTrials
Xenon Pharmaceuticals3
Cybin IRL2
Definium Therapeutics US2
Syndeio Biosciences2
Alto Neuroscience1
Shandong Provincial Hospital1

Sponsors with the most current trials registered for this condition.

07

Questions about Neurocrine Biosciences trials

How many clinical trials does Neurocrine Biosciences sponsor?

Neurocrine Biosciences is the lead sponsor of 15 current trials on ClinicalTrials.gov in our USA and UK registers, and 4 authorised or ongoing trials in the EU register (CTIS), as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are Neurocrine Biosciences trials recruiting?

Yes. 13 of its 15 ClinicalTrials.gov trials are recruiting. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Which drugs is Neurocrine Biosciences testing?

Its current trials name 3 drugs and biologicals as interventions. The most frequent are NBI-1117568 (6), NBI-1065845 (5) and Crinecerfont (2). The number in brackets is how many of its trials name each drug.

Where does this information come from?

Every trial, status, phase and condition on this page is copied from public ClinicalTrials.gov and EU CTIS records by a daily sync, grouped by the sponsor name each registry records. It says nothing about the organisation beyond its registered trials, and it is not medical advice.

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How this page is built

Everything on this page is copied from public registry records — it is not written from memory, and nothing here describes the organisation beyond its registered trials. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our trial registers and groups every current trial by its lead sponsor name, ignoring legal-form suffixes such as Inc. or Ltd. A small, hand-checked list joins the same organisation's different registry names (for example its EU legal entity). There is no AI drafting and no per-sponsor editorial pass. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The the registries data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.