Edwards Lifesciences is the lead sponsor of 34 current clinical trials in our USA, UK and China registers. 12 are recruiting patients now. The most common phase is Not applicable. The most-studied condition is Mitral Regurgitation.
| Study | Phase | Status | Start | Registers |
|---|---|---|---|---|
|
Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial
NCT04097145 · Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease
|
Not applicable | Recruiting | 2019-12 | USA |
|
The ENCIRCLE Trial
NCT04153292 · ClinicalTrials.gov ↗ · Mitral Regurgitation, Mitral Valve Insufficiency
|
Not applicable | Recruiting | 2020-11 | UK, USA |
|
Autus Valve Continued Access Study (CAS)
NCT07466745 · Congenital Heart Disease
|
Not applicable | Recruiting | 2026-07 | USA |
|
TTVR STRONG Under Coverage With Evidence Development (CED) Study
NCT06833476 · Tricuspid Regurgitation
|
Observational | Recruiting | 2025-03 | USA |
|
MITRIS China Post Market Clinical Follow-up (PMCF) Study
NCT07059793 · ClinicalTrials.gov ↗ · Mitral Valve Replacement
|
Observational | Recruiting | 2025-07 | China |
|
Real World European Investigation of Safety and Clinical Efficacy of the EVOQUE System (TRISCEND III EU)
NCT06569602 · ClinicalTrials.gov ↗ · Tricuspid Valve Regurgitation, Heart Valve Diseases, Cardiovascular Diseases
|
Observational | Recruiting | 2024-10 | UK |
|
ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve
NCT05172960 · ClinicalTrials.gov ↗ · Aortic Stenosis, Severe
|
Not applicable | Recruiting | 2022-06 | USA |
|
PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR
NCT04889872 · ClinicalTrials.gov ↗ · Aortic Stenosis, Calcific, Aortic Valve Stenosis
|
Not applicable | Recruiting | 2021-10 | USA |
|
TVMR With the INNOVALVE System Trial - Early Feasibility Study
NCT04919980 · ClinicalTrials.gov ↗ · Mitral Valve Regurgitation (Degenerative or Functional)
|
Not applicable | Recruiting | 2022-09 | USA |
|
COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction
NCT02744677 · ClinicalTrials.gov ↗ · Complex Congenital Heart Defect, Dysfunctional RVOT Conduit, Pulmonary Valve Insufficiency
|
Not applicable | Recruiting | 2016-07 | USA |
|
PARTNER 3 Trial - Aortic Valve-in-Valve
NCT03003299 · ClinicalTrials.gov ↗ · Aortic Stenosis, Aortic Stenosis, Severe
|
Not applicable | Recruiting | 2017-01 | USA |
|
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
NCT05172973 · ClinicalTrials.gov ↗ · Aortic Valve Insufficiency, Aortic Valve Stenosis
|
Not applicable | Recruiting | 2023-11 | USA |
|
TRIFORMIS RESILIA Real-world Study Assessing Safety and Performance (TRIBLAZE Study)
NCT07684313 · ClinicalTrials.gov ↗ · Heart Valve Diseases, Heart Diseases, Cardiovascular Diseases
|
Observational | Not yet open | 2026-08 | USA |
|
Autus Valve Pivotal Study
NCT05006404 · Congenital Heart Disease
|
Not applicable | Active, closed | 2024-02 | USA |
|
China S3 PMS: SAPIEN 3 China Post Market Registry Study
NCT05168826 · Aortic Stenosis, Severe
|
Observational | Active, closed | 2022-01 | China |
|
Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve
NCT05526560 · Mitral Stenosis, Mitral Valve Insufficiency
|
Observational | Active, closed | 2023-01 | UK, USA |
|
ALTERRA Post-Approval Study
NCT05378386 · Pulmonary Valve Insufficiency, Complex Congenital Heart Defect, Tetralogy of Fallot
|
Observational | Active, closed | 2022-05 | USA |
|
Edwards EVOQUE Eos MISCEND Study
NCT02718001 · Mitral Valve Regurgitation (Degenerative or Functional)
|
Not applicable | Active, closed | 2015-02 | USA |
|
MiCLASP Post Market Clinical Follow-Up (PMCF) Study
NCT04430075 · ClinicalTrials.gov ↗ · Mitral Regurgitation, Mitral Insufficiency
|
Observational | Active, closed | 2019-08 | UK |
|
SAPIEN 3 Ultra System PMCF
NCT04555967 · ClinicalTrials.gov ↗ · Aortic Valve Stenosis
|
Observational | Active, closed | 2020-06 | UK |
|
PARTNER 3 Trial - Mitral Valve in Valve
NCT03193801 · Mitral Valve Insufficiency, Mitral Valve Disease, Mitral Valve Regurgitation
|
Not applicable | Active, closed | 2018-02 | USA |
|
Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
NCT03706833 · Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency
|
Not applicable | Active, closed | 2018-11 | USA |
|
ALTERRA: SAPIEN 3 THV With the Alterra Adaptive Prestent
NCT03130777 · ClinicalTrials.gov ↗ · Pulmonary Disease, Transcatheter Pulmonary Valve Replacement (TPVR), Tetralogy of Fallot
|
Not applicable | Active, closed | 2017-08 | USA |
|
Beating Heart Mitral Valve Repair With the HARPOON™ System
NCT04375332 · ClinicalTrials.gov ↗ · Mitral Regurgitation
|
Not applicable | Active, closed | 2020-12 | USA |
|
2019-06 TRISCEND Study
NCT04221490 · ClinicalTrials.gov ↗ · Tricuspid Valve Regurgitation, Heart Valve Diseases, Cardiovascular Diseases
|
Not applicable | Active, closed | 2020-05 | USA |
|
Early Feasibility Study - Edwards APTURE Transcatheter Shunt System
NCT03523416 · ClinicalTrials.gov ↗ · Heart Failure
|
Not applicable | Active, closed | 2018-07 | USA |
|
Clinical Study of Edwards Cardioband FIT Valve Repair System
NCT03382457 · ClinicalTrials.gov ↗ · Tricuspid Regurgitation
|
Not applicable | Active, closed | 2018-07 | USA |
|
COMPASSION S3 Post-Approval Study
NCT04860765 · ClinicalTrials.gov ↗ · Complex Congenital Heart Defect, Dysfunctional RVOT Conduit, Pulmonary Valve Insufficiency
|
Observational | Active, closed | 2021-04 | USA |
|
ALT-FLOW II Trial of the Edwards APTURE Transcatheter Shunt System
NCT05686317 · ClinicalTrials.gov ↗ · Heart Failure
|
Not applicable | Active, closed | 2023-04 | USA |
|
EARLY TAVR: Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis
NCT03042104 · ClinicalTrials.gov ↗ · Heart Diseases, Aortic Stenosis, Severe
|
Not applicable | Active, closed | 2017-07 | USA |
|
ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis
NCT03517436 · ClinicalTrials.gov ↗ · Aortic Valve Stenosis
|
Not applicable | Active, closed | 2018-09 | USA |
|
PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis
NCT02675114 · ClinicalTrials.gov ↗ · Aortic Stenosis
|
Not applicable | Active, closed | 2016-03 | USA |
|
TRISCEND II Pivotal Trial
NCT04482062 · ClinicalTrials.gov ↗ · Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease
|
Not applicable | Active, closed | 2021-04 | USA |
|
INSPIRIS China PMCF Study
NCT05404880 · ClinicalTrials.gov ↗ · Aortic Valve Replacement
|
Observational | Active, closed | 2022-07 | China |
Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Titles and statuses are copied from the registry as published.
| Register | Trials | Recruiting |
|---|---|---|
| Clinical trials in USA | 28 | 10 |
| Clinical trials in UK | 5 | 2 |
| Clinical trials in China | 3 | 1 |
A trial with sites in more than one country appears in each of those registers.
| Sponsor | Trials |
|---|---|
| Abbott Medical Devices | 5 |
| HighLife | 3 |
| Peijia Medical Technology (Suzhou) | 2 |
| Shanghai Shenqi Medical Technology | 1 |
| Pan Xiangbin | 1 |
| Xiamen Cardiovascular Hospital, Xiamen University | 1 |
Sponsors with the most current trials registered for this condition.
Edwards Lifesciences is the lead sponsor of 34 current trials on ClinicalTrials.gov in our USA, UK and China registers, as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.
Yes. 12 of its 34 ClinicalTrials.gov trials are recruiting. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Every trial, status, phase and condition on this page is copied from public ClinicalTrials.gov and EU CTIS records by a daily sync, grouped by the sponsor name each registry records. It says nothing about the organisation beyond its registered trials, and it is not medical advice.
Everything on this page is copied from public registry records — it is not written from memory, and nothing here describes the organisation beyond its registered trials. Each trial links to its own record so you can check it yourself.
This page is built automatically: a daily sync job reads the registry records behind our trial registers and groups every current trial by its lead sponsor name, ignoring legal-form suffixes such as Inc. or Ltd. A small, hand-checked list joins the same organisation's different registry names (for example its EU legal entity). There is no AI drafting and no per-sponsor editorial pass. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The the registries data on this page was last retrieved on 26 Sep 2026.