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Compound · clinical trials

Xgeva clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 4 trials in our China, Taiwan, Germany, Switzerland, Austria, Netherlands and Australia registers that name Xgeva as an intervention. Synced 26 Sep 2026
4Current trials
2Recruiting now
4Lead sponsors
7Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Xgeva is named as an intervention in 4 current clinical trials in our China, Taiwan, Germany, Switzerland, Austria, Netherlands and Australia registers. 2 are recruiting patients now. The most common phase is Phase 4. The sponsor with the most trials is Amgen (1). The most-studied condition is Giant Cell Tumor of Bone.

Trials by status

  • Recruiting250%
  • Active, closed250%

Trials by phase

  • Phase 4250%
  • Phase 3125%
  • Phase 2125%
01

Clinical trials of Xgeva

4 trials
StudyPhaseStatusLead sponsorRegisters
DEnosumab for the Treatment of FIbrous Dysplasia/McCune-Albright Syndrome in Adults (DeFiD)
NCT05966064 · ClinicalTrials.gov ↗ · Fibrous Dysplasia, McCune Albright Syndrome
Phase 4 Recruiting Natasha Appelman-Dijkstra Netherlands
Bone Loss Prevention With Zoledronic Acid or Denosumab in Critically Ill Adults
NCT04608630 · ClinicalTrials.gov ↗ · Critical Illness, Osteoporosis
Phase 2 Recruiting Australian and New Zealand Intensive Care Research Centre Australia
Study of XGEVAยฎ (Denosumab) in Chinese Adults and Skeletally Mature Adolescents With Giant Cell Tumor of the Bone
NCT04586660 · ClinicalTrials.gov ↗ · Giant Cell Tumor of Bone
Phase 4 Active, closed Amgen China, Taiwan
Prevention of Symptomatic Skeletal Events With Denosumab Administered Every 4 Weeks Versus Every 12 Weeks
NCT02051218 · ClinicalTrials.gov ↗ · Metastatic Breast Cancer, Metastatic Prostate Cancer, Bone Metastases
Phase 3 Active, closed Swiss Cancer Institute Germany, Switzerland, Austria

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Xgeva

8 conditions
Giant Cell Tumor of Bone1Metastatic Breast Cancer1Metastatic Prostate Cancer1Bone Metastases1Fibrous Dysplasia1McCune Albright Syndrome1Critical Illness1Osteoporosis1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Amgen1
Swiss Cancer Institute1
Natasha Appelman-Dijkstra1
Australian and New Zealand Intensive Care Research Centre1
04

By country register

RegisterTrialsRecruiting
Clinical trials in China10
Clinical trials in Taiwan10
Clinical trials in Germany10
Clinical trials in Switzerland10
Clinical trials in Austria10
Clinical trials in Netherlands11
Clinical trials in Australia11

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Xgeva trials

How many clinical trials are testing Xgeva?

4 current trials in our China, Taiwan, Germany, Switzerland, Austria, Netherlands and Australia registers name Xgeva as a drug or biological intervention, as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are Xgeva trials recruiting patients?

Yes. 2 of the 4 trials are recruiting: 1 with sites in Netherlands and 1 with sites in Australia. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Xgeva clinical trials?

Amgen (1), Swiss Cancer Institute (1), Natasha Appelman-Dijkstra (1) and Australian and New Zealand Intensive Care Research Centre (1). The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Xgeva works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Xgeva works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Xgeva (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.