SiRNA is named as an intervention in 4 current clinical trials in our UK, USA and China registers. 4 are recruiting patients now. The most common phase is Phase 2. The lead sponsor is ADARx Pharmaceuticals, Inc. The most-studied condition is IgAN.
| Study | Phase | Status | Lead sponsor | Registers |
|---|---|---|---|---|
|
Phase 2 Study of ADX-038 in Complement-Mediated Kidney Disease
NCT06989359 · IgAN, C3G, Complement-mediated Kidney Disease
|
Phase 2 | Recruiting | ADARx Pharmaceuticals, Inc. | UK, USA |
|
Phase 2 Study of ADX-038 in Participants With Geographic Atrophy
NCT06990269 · ClinicalTrials.gov ↗ · Geographic Atrophy Secondary to Age-related Macular Degeneration
|
Phase 2 | Recruiting | ADARx Pharmaceuticals, Inc. | UK, USA |
|
Chinese Adults With Kidney Disease
NCT07522099 · ClinicalTrials.gov ↗ · Immunoglobulin A Nephropathy (IgAN), Complement 3 Glomerulopathy (C3G), IC-MPGN
|
Phase 2 | Recruiting | ADARx Pharmaceuticals, Inc. | China |
|
Safety, Tolerability, PK and PD of ADX-038 in Healthy Participants and Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients
NCT05876312 · Paroxysmal Nocturnal Hemoglobinuria (PNH)
|
Phase 1/2 | Recruiting | ADARx Pharmaceuticals, Inc. | UK |
Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
| Lead sponsor | Trials |
|---|---|
| ADARx Pharmaceuticals, Inc. | 4 |
| Register | Trials | Recruiting |
|---|---|---|
| Clinical trials in UK | 3 | 3 |
| Clinical trials in USA | 2 | 2 |
| Clinical trials in China | 1 | 1 |
A trial with sites in more than one country appears in each of those registers.
4 current trials in our UK, USA and China registers name SiRNA (also registered as ADX-038) as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.
Yes. 4 of the 4 trials are recruiting: 3 with sites in UK, 2 with sites in USA and 1 with sites in China. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
The lead sponsor is ADARx Pharmaceuticals, Inc. The number in brackets is how many trials each organisation leads.
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how SiRNA works or whether it is effective, and it is not medical advice.
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how SiRNA works or whether it is effective. Each trial links to its own record so you can check it yourself.
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists SiRNA (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.