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Compound · clinical trials

Evolocumab

Also listed in trial records as Alirocumab, PCSK9 inhibitor, Repatha, Fibrates, Conventional lipid-lowering therapy
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 12 trials in our China and USA registers that name Evolocumab as an intervention. Synced 24 Sep 2026
12Trials tracked
8Recruiting now
10Lead sponsors
2Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

Evolocumab is named as a drug or biological intervention in 12 clinical trials in our China and USA trial registers, 8 of which are recruiting. Lead sponsors include General Hospital of Shenyang Military Region (2), Yun Dai Chen (2) and Amgen (1). Registered phases: Phase 4, Not applicable, Observational, Phase 2/3 and Phase 2. Conditions studied include Acute Myocardial Infarction; Cardiovascular Disease; Myocardial Infarction.

Evolocumab also has an approved-drug profile on this site (FDA label data): Repatha (Evolocumab) →
01

Clinical trials of Evolocumab

12 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT03753555 The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques (ClinicalTrials.gov ↗)
Stroke, Ischemic, Atherosclerosis, Cerebral
Phase 4 Recruiting General Hospital of Shenyang Military Region China
NCT05292404 Impact of Early PCSK9 Inhibitor Treatment on Heart After Acute Myocardium Infarction (ClinicalTrials.gov ↗)
Acute Myocardial Infarction
Phase 4 Recruiting Shanghai Tong Ren Hospital China
NCT07612774 CAPRA-EVO: a Randomized Serial PCCT Trial of Early Evolocumab After ACS (ClinicalTrials.gov ↗)
Coronary, Coronary Artery Disease
Phase 4 Recruiting West China Hospital China
NCT07477704 A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia (ClinicalTrials.gov ↗)
Hypercholesterolemia
Phase 2 Recruiting Regeneron Pharmaceuticals USA
NCT04847752 Study of Predictive Factors Related to Prognosis of Patients With Ischemic Stroke Due to Large-artery Atherosclerosis (ClinicalTrials.gov ↗)
Ischemic Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis)
Observational Recruiting Tongji Hospital China
NCT06738758 Multicenter Real-World Cohort Study Evaluating the Impact of Early Intensive Lipid-Lowering Therapy on the Prognosis of Acute Coronary Syndrome Patients(ELITE-ACS) (ClinicalTrials.gov ↗)
Acute Coronary Syndromes
Observational Recruiting Yun Dai Chen China
NCT05397405 Improving Blood Lipid Management in Symptomatic Intracranial Atherosclerotic Stenosis on Clinical Outcome (ClinicalTrials.gov ↗)
Intracranial Artery Stenosis
Not applicable Recruiting Nanjing First Hospital, Nanjing Medical University China
NCT07388420 Adding Evolocumab to Conventional Lipid-lowering Therapy for Hypertriglyceridemia Induced Acute Pancreatitis (ClinicalTrials.gov ↗)
Hypertriglyceridemia Induced Acute Pancreatitis
Not applicable Recruiting General Hospital of Shenyang Military Region China
NCT07174375 PCSK9 Inhibitors in Acute Ischemic Stroke Patients Undergoing Endovascular Therapy (ClinicalTrials.gov ↗)
Acute Ischemic Stroke
Phase 2/3 Not yet open Nanfang Hospital, Southern Medical University China
NCT06730802 Protective Effect of PCSK9 Inhibitor Against Negative Inflammatory Response and Organ Dysfunction After Coronary Artery Bypass Grafting (PANDA VIII) (ClinicalTrials.gov ↗)
Myocardial Ischaemic Syndrome, Coronary Heart Disease
Not applicable Not yet open Nanjing Medical University China
NCT06854523 Assessing Coronary Non-Culprit Plaque Early with Start of PCSK9 Inhibitors in Acute Myocardial Infarction (ACCESS-AMI) (ClinicalTrials.gov ↗)
Acute Myocardial Infarction
Not applicable Not yet open Yun Dai Chen China
NCT05284747 EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction
Cardiovascular Disease, Myocardial Infarction, Stroke
Phase 4 Active, closed Amgen USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

18 conditions
Condition (as registered)Trials
Acute Myocardial Infarction2
Cardiovascular Disease1
Myocardial Infarction1
Stroke1
Coronary Revascularization1
Hypertriglyceridemia Induced Acute Pancreatitis1
Coronary1
Coronary Artery Disease1
Acute Ischemic Stroke1
Hypercholesterolemia1
Intracranial Artery Stenosis1
Stroke, Ischemic1
Atherosclerosis, Cerebral1
Myocardial Ischaemic Syndrome1
Coronary Heart Disease1
Ischemic Stroke1
Large-Artery Atherosclerosis (Embolus/Thrombosis)1
Acute Coronary Syndromes1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
General Hospital of Shenyang Military Region2
Yun Dai Chen2
Amgen1
West China Hospital1
Nanfang Hospital, Southern Medical University1
Regeneron Pharmaceuticals1
Shanghai Tong Ren Hospital1
Nanjing First Hospital, Nanjing Medical University1
Nanjing Medical University1
Tongji Hospital1
04

Trials by country register

RegisterEvolocumab trials
Clinical trials in China10
Clinical trials in USA2

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Evolocumab works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Evolocumab (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.