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Compound · clinical trials

Berzosertib clinical trials

Also listed in trial records as 2-Pyrazinamine, M 6620, M6620, VX 970
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 3 trials in our Israel register that name Berzosertib as an intervention. Synced 27 Sep 2026
3Current trials
0Recruiting now
1Lead sponsor
1Country register
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Berzosertib is named as an intervention in 3 current clinical trials in our Israel register. None are recruiting at the moment. The most common phase is Phase 2. The lead sponsor is National Cancer Institute (NCI). The most-studied condition is Ovarian Serous Tumor.

Where Berzosertib is approved

All regulators →
USUnited States (FDA)
No FDA approval of a single-substance product in Drugs@FDA
First original NDA/BLA approval
EUEuropean Union (EMA)
No centralised EU authorisation (it may be authorised nationally)
First centralised authorisation
CACanada (Health Canada)
No new-drug Notice of Compliance since 1994
First new-drug NOC

From the regulators' own registers: FDA Drugs@FDA, the EMA medicines list and Health Canada's Notice of Compliance database. Dates are the first listed approval of a product containing only this substance; combination products and nationally authorised EU medicines are not counted.

Trials by status

  • Active, closed3100%

Trials by phase

  • Phase 2267%
  • Phase 1133%
01

Clinical trials of Berzosertib

3 trials
StudyPhaseStatusLead sponsorRegisters
Gemcitabine Hydrochloride Alone or With M6620 in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
NCT02595892 · ClinicalTrials.gov ↗ · Ovarian Serous Tumor, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma
Phase 2 Active, closed National Cancer Institute (NCI) Israel
M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castration-Resistant Prostate Cancer
NCT03517969 · ClinicalTrials.gov ↗ · Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma, Stage IV Prostate Cancer AJCC v8
Phase 2 Active, closed National Cancer Institute (NCI) Israel
M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery
NCT02595931 · ClinicalTrials.gov ↗ · Metastatic Colorectal Carcinoma, Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Solid Neoplasm
Phase 1 Active, closed National Cancer Institute (NCI) Israel

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Berzosertib

11 conditions
Ovarian Serous Tumor1Recurrent Fallopian Tube Carcinoma1Recurrent Ovarian Carcinoma1Recurrent Primary Peritoneal Carcinoma1Castration-Resistant Prostate Carcinoma1Metastatic Prostate Carcinoma1Stage IV Prostate Cancer AJCC v81Metastatic Colorectal Carcinoma1Metastatic Lung Small Cell Carcinoma1Metastatic Malignant Solid Neoplasm1Metastatic Pancreatic Carcinoma1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
National Cancer Institute (NCI)3
04

By country register

RegisterTrialsRecruiting
Clinical trials in Israel30

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Berzosertib trials

How many clinical trials are testing Berzosertib?

3 current trials in our Israel register name Berzosertib (also registered as 2-Pyrazinamine) as a drug or biological intervention, as of the registry sync on 27 September 2026. Completed and withdrawn studies are not counted.

Are Berzosertib trials recruiting patients?

Not at the moment. None of the 3 trials in our registers is recruiting; they are active but closed to enrolment, not yet open, or enrolling by invitation. Only the study team can confirm whether a patient is eligible.

Who sponsors Berzosertib clinical trials?

The lead sponsor is National Cancer Institute (NCI). The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Berzosertib works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Berzosertib works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Berzosertib (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 27 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.