A Study of XB628 Alone and in Combination With Zanzalintinib in Participants With Recurrent Advanced or Metastatic Solid Tumors
Condition(s) studied
Investigational drug(s) / intervention(s)
XB628: Intravenous infusion(s)
Zanzalintinib: Oral tablet(s)
Study summary
This study consists of a Dose-Escalation stage and a Dose Expansion stage. The primary purpose of the dose escalation stage is to determine the maximum tolerated dose (MTD) and/or recommended dosage(s) for expansion (RDE\[s\]); and the dose expansion stage is to evaluate the preliminary antitumor activity of XB628 as a single agent and in combination with zanzalintinib.
Eligibility
Primary outcome measure(s)
- Dose Escalation Cohort: Number of Participants with Dose Limiting Toxicities (DLTs) — 21 days
- Dose Escalation Cohort: Number of Participants With Treatment Emergent Adverse Events (TEAEs) — Up to 27 months
- Dose Expansion Cohort: Objective Response Rate (ORR) — Up to 27 months
Trial sites (11)
| Facility | City | Region | Status |
|---|---|---|---|
| Exelixis Clinical Site #5 | San Francisco | California | Recruiting |
| Exelixis Clinical Site #4 | New Haven | Connecticut | Recruiting |
| Exelixis Clinical Site #8 | Tampa | Florida | Recruiting |
| Exelixis Clinical Site #10 | Boston | Massachusetts | Recruiting |
| Exelixis Clinical Site #11 | Boston | Massachusetts | Recruiting |
| Exelixis Clinical Site #6 | St Louis | Missouri | Recruiting |
| Exelixis Clinical Site #7 | New York | New York | Recruiting |
| Exelixis Clinical Site #1 | Hickory | North Carolina | Recruiting |
| Exelixis Clinical Site #3 | Nashville | Tennessee | Recruiting |
| Exelixis Clinical Site #9 | Houston | Texas | Recruiting |
| Exelixis Clinical Site #2 | San Antonio | Texas | Recruiting |
More Exelixis trials in the USA
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06952010 on ClinicalTrials.gov ↗ ← All trials in the USA